314263-24-6

Basic information

• Product Name: (R)-2-(4-Chloro-phenoxy)-propionyl chloride
• Synonyms: (R)-2-(4-Chloro-phenoxy)-propionyl chloride
• CAS NO: 314263-24-6
• Molecular Weight: 219.067
• Mol File: 314263-24-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-Chloro-phenoxy)-propionyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-Chloro-phenoxy)-propionyl chloride(314263-24-6)
• EPA Substance Registry System: (R)-2-(4-Chloro-phenoxy)-propionyl chloride(314263-24-6)

Safety Data

• Hazardous Substances Data: 314263-24-6(Hazardous Substances Data)

Upstream product

• 99210-92-1 (R)-2-(4-chlorophenoxy)propanoic acid methyl ester 
• 106-48-9 4-chloro-phenol 
• 3307-39-9 (R)-2-(4-chlorophenoxy)propanoic acid 

Downstream Products

• 155156-11-9 (R)-2-(4-Chloro-phenoxy)-propionic acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester 

Relevant articles and documents

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase

A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as determined by X-ray crystallography of the enzyme-inhibitor complex. Guided by both molecular modeling and traditional SAR, the enzyme activity of the initial hit was improved by approximately 100-fold, yielding a series of potent and selective NS5B inhibitors with IC50 values as low as 10 nM. These compounds were also inhibitors of the HCV replicon in cultured HUH7 cells.

Carboxylic acids and chloride conductance in skeletal muscle: Influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids

Some analogues of 2-(4-chloro-phenoxy)-propionic acid have been synthesized to evaluate the influence on the skeletal muscle chloride conductance of the distance between the phenolic and the carboxylic groups and/or the presence of substituents and chiral centers differently located on the carbon chain. Absolute configuration and/or chiroptical properties of the chiral compounds synthesized have been determined. These compounds, differently from fibrates, show a very low activity on chloride conductance and no remarkable correlation of this parameter with the absolute configuration.