314268-24-1

Basic information

• Product Name: 5-cyano-N-[4-(2-hydroxyethyl)-phenyl]-4-thien-2-ylpyrimidine-2-amine
• CAS NO: 314268-24-1
• Molecular Weight: 322.39
• Mol File: 314268-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-cyano-N-[4-(2-hydroxyethyl)-phenyl]-4-thien-2-ylpyrimidine-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyano-N-[4-(2-hydroxyethyl)-phenyl]-4-thien-2-ylpyrimidine-2-amine(314268-24-1)
• EPA Substance Registry System: 5-cyano-N-[4-(2-hydroxyethyl)-phenyl]-4-thien-2-ylpyrimidine-2-amine(314268-24-1)

Safety Data

• Hazardous Substances Data: 314268-24-1(Hazardous Substances Data)

Upstream product

• 52200-22-3 2-(2-thienylcarbonyl)-3-(dimethylamino)acrylonitrile 
• 420-04-2 CYANAMID 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 33898-90-7 2-Thenoylacetonitrile 

Downstream Products

• 314268-23-0 5-Cyano-4-thien-2-yl-N-[4-(2-p-toluenesulphonyloxyethyl)phenyl]pyrimidine-2-amine 

Relevant articles and documents

4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

A novel series of 4-aryl-5-cyano-2-aminopyrimidines were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure-activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization.