315683-89-7

Basic information

• Product Name: dimethyl 5-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}isophthalate
• Synonyms: dimethyl 5-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}isophthalate
• CAS NO: 315683-89-7
• Molecular Formula: C23H18N2O5S
• Molecular Weight: 434.46442
• Mol File: 315683-89-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 612.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.326±0.06 g/cm3(Predicted)
• PKA: 1.48±0.40(Predicted)
• CAS DataBase Reference: dimethyl 5-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}isophthalate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 5-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}isophthalate(315683-89-7)
• EPA Substance Registry System: dimethyl 5-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}isophthalate(315683-89-7)

Safety Data

• Hazardous Substances Data: 315683-89-7(Hazardous Substances Data)

Upstream product

• 122-00-9 para-methylacetophenone 
• 374104-63-9 4-chloro-5-(p-tolyl)thieno[2,3-d]pyrimidine 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 17509-21-6 5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one 
• 15854-08-7 ethyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate 

Relevant articles and documents

Identification of 4-methoxythieno[2,3-d]pyrimidines as FGFR1 inhibitors

Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. Results. In vitro experiments showed that 9 of 23 tested compounds possess inhibitory activity against FGFR1 with IC50 values in the range from 0.9 to 5.6 μM. Conclusions. Nine FGFR1 inhibitors were developed. The mode of compounds binding with the ATP-acceptor site was determined using molecular docking methods and the dependence of the compounds’ activity on the substituents R1, R4 and R5 was evaluated.