316-61-0

Basic information

• Product Name: 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE
• Synonyms: AKOS BAR-1334;2'-FLUORO[1,1'-BIPHENYL]-2-AMINE
• CAS NO: 316-61-0
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.21
• Mol File: 316-61-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 298.4±15.0 °C(Predicted)
• Appearance: /
• Density: 1.161±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.89±0.10(Predicted)
• CAS DataBase Reference: 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE(316-61-0)
• EPA Substance Registry System: 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE(316-61-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 316-61-0(Hazardous Substances Data)

Usage

General Description

2'-Fluoro[1,1'-biphenyl]-2-amine is a chemical compound with the molecular formula C12H10FN. It is a fluoro substituted biphenyl derivative with an amine functional group. 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE has potential applications in pharmaceutical and organic synthesis due to its unique chemical structure. Its properties and uses may vary depending on the specific application, but it is generally considered to be a building block for the synthesis of more complex organic molecules. 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE may be used in the development of new pharmaceutical drugs or in the production of specialty chemicals. It is important to handle and use this chemical with caution, following proper safety protocols and guidelines.

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Downstream Products

• 76838-48-7 N-benzoyl-N'-(2'-fluoro-2-biphenylyl)thiourea 

Relevant articles and documents

HOST MATERIALS FOR ELECTROLUMINESCENT DEVICES

A compound of Formula I wherein X1 and X2 are independently CRX or N, and at least one of X1 or X2 is CRX; Y is selected from the group consisting of O, S, Se, NR′, BR′, CR′R″, and SiR′R″; R′, and R″ are each independently selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aryl, heteroaryl, and combinations thereof; R is selected from the group consisting of deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; RA, and RC each independently represent mono to the maximum allowable substitution, or no substitution; and each RX, RA, and RC is independently a hydrogen or a substituent selected from the group consisting of deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof, and wherein any two substituents RX, RA, and RC may be optionally joined to form a ring, with the proviso that R does not join with RA to form a ring.

Metal-Oxidant-Free Cobalt-Catalyzed C(sp2)-H Carbonylation of ortho-Arylanilines: An Approach toward Free (NH)-Phenanthridinones

A traceless directing group assisted Co-catalyzed C(sp2)-H carbonylation of ortho-arylanilines for the synthesis of free (NH)-phenanthridinones in metal-based-oxidant-free fashion was accomplished. This protocol employs diisopropyl azodicarboxylate as the CO source and oxygen as the sole oxidant, and provides good yields with various functional tolerance. The methodology has been applied for the total synthesis of PARP inhibitor PJ-34. Furthermore, the kinetic isotopic effect experiments reveal the C-H bond cleavage probably occurred in the rate-determining step.

Synthesis of Triphenylenes Starting from 2-Iodobiphenyls and Iodobenzenes via Palladium-Catalyzed Dual C-H Activation and Double C-C Bond Formation

A novel and facile approach for the synthesis of triphenylenes has been developed via palladium-catalyzed coupling of 2-iodobiphenyls and iodobenzenes. The reaction involves dual palladium-catalyzed C-H activations and double palladium-catalyzed C-C bond formations. A range of unsymmetrically functionalized triphenylenes can be synthesized with the reaction. The approach features readily available starting materials, high atom- and step-economy, and access to various unsymmetrically functionalized triphenylenes.