316-68-7

Basic information

• Product Name: 4-FLUORO-1-ACETONAPHTHONE
• Synonyms: 4'-FLUORO-1'-ACETONAPHTHONE;4-FLUORO-1-ACETONAPHTHONE;1-(4-fluoro-1-naphthyl)ethan-1-one;4-Fluoroacetonaphthone;4-Fluoro-1-acetonaphthone 97%;4-Fluoro-1-acetonaphthone97%;1-ACETYL-4-FLUORONAPHTHALENE, 97%;1-(4-Fluoro-1-naphthalenyl)ethanone
• CAS NO: 316-68-7
• Molecular Formula: C₁₂H₉FO
• Molecular Weight: 188.2
• EINECS: 206-261-9
• Product Categories: Aromatic Halides (substituted);C11 to C12;Carbonyl Compounds;Ketones
• Mol File: 316-68-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 33-35 °C(lit.)
• Boiling Point: 167 °C17 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.203 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.608(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-FLUORO-1-ACETONAPHTHONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-1-ACETONAPHTHONE(316-68-7)
• EPA Substance Registry System: 4-FLUORO-1-ACETONAPHTHONE(316-68-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 316-68-7(Hazardous Substances Data)

Usage

General Description

4-FLUORO-1-ACETONAPHTHONE is a chemical compound that belongs to the class of organic compounds known as benzoyl derivatives. It is a derivative of 1-acetonaphthone in which a fluorine atom is located at the 4-position. 4-FLUORO-1-ACETONAPHTHONE is used in various research and industrial applications, including as a reagent in the synthesis of pharmaceutical compounds and as a precursor in the production of other chemical substances. It is important to handle 4-FLUORO-1-ACETONAPHTHONE with care, as it may pose health and environmental risks if not properly managed.

Upstream product

• 321-38-0 1-Fluoronaphthalene 
• 75-36-5 acetyl chloride 

Downstream Products

• 1245640-77-0 C₁₉H₁₃F₂NO 
• 1245640-79-2 C₁₉H₁₃ClFNO 
• 1245640-81-6 C₁₉H₁₄FNO 
• 1245640-78-1 C₂₀H₁₆FNO₂ 
• 1245640-80-5 C₁₉H₁₃BrFNO 

Relevant articles and documents

Proton and Carbon NMR Spectra of 4-Substituted 1-Acetylnaphthalenes

The proton and carbon spectra of ten 4-X-1-acetylnaphthalenes have been assigned.Shift correlations have been made with benzene substituent-induced chemical shifts (SCS, Lynch plots) and with dual substituent parameters (DSP) in the manner successfully done for many series of 1,4-disubstituted benzenes.The results obtained are compared with those for 4-X-acetophenones and 1-X-naphthalenes.The main conclusions are (i) the carbon para to the variable substituent X is more sensitive to change of substituent in the naphthalenes than in the benzenes, (ii) of the carbonsortho to the variable substituent X, that at C-3 is more sensitive and that at C-4a is less sensitive, to change of substituent in the naphthalenes than in the benzenes, (iii) the effect of the 4-substituents on the shift of H-8 in 1-acetylnaphthalenes is due mainly to changes in the carbonyl dipole affecting the diamagnetic screening of the proton.

FUSED BENZENE DERIVATIVE AND USE

The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3' (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5' (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.

Preparation of a series of substituted fluoromethylnaphthalenes

A series of 22 3- and 4-substituted 1-fluoromethylnaphthalenes have been synthesized.Details of practical procedures for the preparation of all intermediates are described, and physical properties for all of the substituted naphthalenes synthesized, and spectral parameters for 51 previously unknown compounds, are given.