31638-90-1Relevant articles and documents
Near-Infrared Phosphorus-Substituted Rhodamine with Emission Wavelength above 700 nm for Bioimaging
Chai, Xiaoyun,Cui, Xiaoyan,Wang, Baogang,Yang, Fan,Cai, Yi,Wu, Qiuye,Wang, Ting
, p. 16754 - 16758 (2015)
Phosphorus has been successfully fused into a classic rhodamine framework, in which it replaces the bridging oxygen atom to give a series of phosphorus-substituted rhodamines (PRs). Because of the electron-accepting properties of the phosphorus moiety, wh
Voltage Imaging with a NIR-Absorbing Phosphine Oxide Rhodamine Voltage Reporter
Gonzalez, Monica A.,Walker, Alison S.,Cao, Kevin J.,Lazzari-Dean, Julia R.,Settineri, Nicholas S.,Kong, Eui Ju,Kramer, Richard H.,Miller, Evan W.
supporting information, p. 2304 - 2314 (2021/02/16)
The development of fluorescent dyes that emit and absorb light at wavelengths greater than 700 nm and that respond to biochemical and biophysical events in living systems remains an outstanding challenge for noninvasive optical imaging. Here, we report the design, synthesis, and application of near-infrared (NIR)-absorbing and -emitting optical voltmeter based on a sulfonated, phosphine-oxide (po) rhodamine for voltage imaging in intact retinas. We find that po-rhodamine based voltage reporters, or poRhoVRs, display NIR excitation and emission profiles at greater than 700 nm, show a range of voltage sensitivities (13 to 43% ΔF/F per 100 mV in HEK cells), and can be combined with existing optical sensors, like Ca2+-sensitive fluorescent proteins (GCaMP), and actuators, like light-activated opsins ChannelRhodopsin-2 (ChR2). Simultaneous voltage and Ca2+ imaging reveals differences in activity dynamics in rat hippocampal neurons, and pairing poRhoVR with blue-light based ChR2 affords all-optical electrophysiology. In ex vivo retinas isolated from a mouse model of retinal degeneration, poRhoVR, together with GCaMP-based Ca2+ imaging and traditional multielectrode array (MEA) recording, can provide a comprehensive physiological activity profile of neuronal activity, revealing differences in voltage and Ca2+ dynamics within hyperactive networks of the mouse retina. Taken together, these experiments establish that poRhoVR will open new horizons in optical interrogation of cellular and neuronal physiology in intact systems.
Synthesis and properties of novel polyimide fibers containing phosphorus groups in the main chain
Zhao, Yong,Feng, Tao,Li, Guomin,Liu, Fangfang,Dai, Xuemin,Dong, Zhixin,Qiu, Xuepeng
, p. 42482 - 42494 (2016/05/19)
A series of polyamic acid copolymers (co-PAAs) containing phosphorous groups in the main chain were synthesized using different ratios of two diamines, i.e., bis(3-aminophenyl)methyl phosphine oxide (DAMPO) and 4,4′-oxydianiline (ODA), with 3,3′,4,4′-biphenyltetracarboxylic dianhydride (s-BPDA) by polycondensation in N,N′-dimethyacetamide (DMAc). The co-PAA solutions were spun into fibers by a dry-jet wet spinning process, and then polyimide copolymer (co-PI) fibers were obtained by thermal imidization. ATR-FTIR spectra and elemental analysis confirmed the chemical structure of PAA and PI fibers. The as-prepared PI fibers have smooth and dense surface as well as uniform diameter. Compared with the blank PI-0, the Tg values of co-PI fibers increased considerably with the increase in DAMPO content. TGA results indicated that the co-PI fibers possessed good thermal stability up to 510 °C and a residual char yield of up to 61% at 850 °C. All co-PI fibers exhibited excellent elongation, and their tensile strength and modulus can reach 0.9 GPa and 14.97 GPa when the molar ratio of DAMPO/ODA was 6/4 and the draw ratio was 3.0. The relationship between microstructure and mechanical property is also discussed.
