317-46-4

Basic information

• Product Name: 2-FLUORO-3-NITROBENZOIC ACID
• Synonyms: Benzoic acid,2-fluoro-3-nitro-;2-FLUORO-3-NITROBENZOIC ACID;2-Fluoro-3-nitrobenzoic acid+B244;2-Fluoro-3-nitrobenzoic acid 99%;3-Carboxy-2-fluoronitrobenzene;3-Pyridinecarboxylic acid, 4-aMino-
• CAS NO: 317-46-4
• Molecular Formula: C₇H₄FNO₄
• Molecular Weight: 185.11
• EINECS: 1312995-182-4
• Product Categories: Fluorine series;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 317-46-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 347.6 °C at 760 mmHg
• Flash Point: 164 °C
• Appearance: /Solid
• Density: 1.568 g/cm³
• Vapor Pressure: 2.01E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 2.32±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• Stability: Hygroscopic
• CAS DataBase Reference: 2-FLUORO-3-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-NITROBENZOIC ACID(317-46-4)
• EPA Substance Registry System: 2-FLUORO-3-NITROBENZOIC ACID(317-46-4)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 317-46-4(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow crystalline powder

Uses

2-Fluoro-3-nitrobenzoic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

InChI:InChI=1/C7H4FNO4/c8-6-4(7(10)11)2-1-3-5(6)9(12)13/h1-3H,(H,10,11)

Upstream product

• 445-29-4 o-fluoro-benzoic acid 
• 1214328-20-7 2-fluoro-3-nitrobenzonitrile 
• 124-38-9 carbon dioxide 
• 1493-27-2 ortho-nitrofluorobenzene 
• 13073-29-5 2-methyl-6-nitrophenol 
• 95-48-7 ortho-cresol 
• 96516-29-9 2-fluoro-3-nitrobenzaldehyde 
• 437-86-5 2-fluoro-3-nitrotoluene 
• 95-52-3 2-Fluorotoluene 

Downstream Products

• 1254567-33-3 (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone 
• 1312942-00-9 (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone 
• 1312942-01-0 N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide 
• 1312940-70-7 2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide 
• 1448807-15-5 2-fluoro-3-(oxazolo[4,5-b]pyridin-2-yl)aniline 
• 1448806-57-2 N-(2-fluoro-3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide 
• 1644598-67-3 benzyl 2-{[(2'R)-1'-methoxy-1'-oxopropan-2’-yl]amino}-3-nitrobenzoate 
• 1644598-68-4 benzyl 2-{[(2'S)-1’-methoxy-1’-oxopropan-2'-yl]amino}-3-nitrobenzoate 
• 1644598-69-5 benzyl (3R)-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate 
• 1644598-70-8 benzyl (3S)-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate 
• 1644598-66-2 benzyl 2-fluoro-3-nitrobenzoate 

Relevant articles and documents

Preparation method of 2-fluoro-3-nitrobenzoic acid

The invention discloses a preparation method of 2-fluoro-3-nitrobenzoic acid (II), which comprises the following steps: carrying out fluorine ortho-lithiation, dry ice carbonyl insertion reaction and acidic hydrolysis on 2-fluoronitrobenzene (I) by utilizing lithium diisopropylamide or tert-butyl lithium under a low-temperature condition to prepare the target product 2-fluoro-3-nitrobenzoic acid. The method has the advantages of mild reaction conditions, no need of transition metal catalysis, good selectivity, high yield, simple and efficient process, environmental protection, economy and suitableness for large-scale preparation;.

IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS

A series of 2-imino-6-methyltetrahydropyrimidin-4(lH)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.