31803-00-6

Basic information

• Product Name: 5-BENZYL-1,3,4-OXADIAZOL-2-YLAMINE
• Synonyms: 5-BENZYL-1,3,4-OXADIAZOL-2-YLAMINE;2-AMINO-5-BENZYL-1,3,4-OXADIAZOL;2-AMINO-5-BENZYL-1,3,4-OXADIAZOLE;5-benzyl-1,3,4-oxadiazol-2-amine;5-(phenylmethyl)-1,3,4-oxadiazol-2-amine
• CAS NO: 31803-00-6
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Mol File: 31803-00-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 161-163°C
• Boiling Point: 359.1°C at 760 mmHg
• Flash Point: 170.9°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 2.44E-05mmHg at 25°C
• Refractive Index: 1.604
• PKA: -0.50±0.13(Predicted)
• CAS DataBase Reference: 5-BENZYL-1,3,4-OXADIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BENZYL-1,3,4-OXADIAZOL-2-YLAMINE(31803-00-6)
• EPA Substance Registry System: 5-BENZYL-1,3,4-OXADIAZOL-2-YLAMINE(31803-00-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 31803-00-6(Hazardous Substances Data)

Usage

Uses

5-benzyl-1,3,4-oxadiazol-2-amine is a useful chemical for the synthesis process of 6,?7-?dimethoxy quinazoline derivatives for the purpose as VEGFR-?2 tyrosine kinase inhibitors as potential anticancer agents.

InChI:InChI=1/C9H9N3O/c10-9-12-11-8(13-9)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,10,12)

Upstream product

• 122-78-1 phenylacetaldehyde 
• 29313-28-8 1-phenylacetyl-thiosemicarbazide 
• 937-39-3 2-phenylacetylhydrazine 
• 35604-35-4 5-benzyl[1.2.4]oxadiazol-3-ylamine 
• 506-68-3 bromocyane 
• 15129-13-2 phenylacetylsemicarbazide 
• 1722-94-7 phenylacetaldehyde semicarbazone 

Downstream Products

• 25306-19-8 2-benzyl-imidazo[2,1-b][1,3,4]oxadiazole-5,6-dione 
• 14631-95-9 N-(5-benzyl-[1,3,4]oxadiazol-2-yl)-acetamide 
• 6756-31-6 1-(5-benzyl-[1,3,4]oxadiazol-2-yl)-3-phenyl-urea 
• 14632-09-8 N-(5-benzyl-[1,3,4]oxadiazol-2-yl)-propionamide 
• 34254-13-2 5-benzyl-3-chloroacetyl-3H-[1,3,4]oxadiazol-2-ylideneamine 
• 37423-06-6 N'-(5-benzyl-[1,3,4]oxadiazol-2-yl)-N,N-dimethyl-formamidine 
• 51324-03-9 2-benzyl-5-oxo-5H-[1,3,4]oxadiazolo[3,2-a]pyrimidine-7-carboxylic acid ethyl ester 
• 132380-91-7 N-(5-benzyl-1,3,4-oxadiazol-2-yl) benzamidine 
• 132380-93-9 N-(5-benzyl-1,3,4-oxadiazol-2-yl) acetamidine 
• 132380-92-8 N-(5-benzyl-1,3,4-oxadiazol-2-yl) 4-chlorobenzamidine 
• 76441-28-6 5-Benzyl-3-methyl-Δ⁴-1,3,4-oxadiazolin-2-imin 
• 116862-13-6 2-[(5-Benzyl-[1,3,4]oxadiazol-2-ylamino)-methylene]-malonic acid diethyl ester 
• 116862-18-1 2-Benzyl-5-oxo-5H-[1,3,4]oxadiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of N-pyrimidin[1,3,4]oxadiazoles and N-pyrimidin[1,3,4]-thiadiazoles from 1,3,4-oxadiazol-2-amines and 1,3,4-thiadiazol-2-amines via Pd-catalyzed heteroarylamination

An efficient and practical procedure was developed to prepare various N-pyrimidin[1,3,4]oxadiazole and thiadiazole scaffolds using a Buchwald-type coupling. The products of this reaction are otherwise difficult to access and could be used as building bloc

A convenient synthesis of 5-substituted 2-amino-1,3,4-oxadiazoles from corresponding acylthiosemicarbazides using iodine and Oxone

A convenient methodology has been developed for the synthesis of substituted 2-amino-1,3,4-oxadiazoles from corresponding acylthiosemicarbazides using catalytic amount of iodine/KI in the presence of Oxone as a bulk oxidant. This offers the adv

Synthesis and Biological Activity of 2-Substituted 6-Carbethoxy-5(H)-oxo-1,3,4-oxadiazolopyrimidines

Several 2-substituted 6-carbethoxy-5(H)-oxo-1,3,4-oxadiazolopyrimidines (4) have been synthesised by the reaction of 5-substituted 2-amino-1,3,4-oxadiazoles (1) with diethyl ethoxymethylenemalonate (2).These compounds have been screened for their p