318249-44-4

Basic information

• Product Name: Butanoic acid, 4-hydroxy-3-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (3R)-
• CAS NO: 318249-44-4
• Molecular Formula: C13H17NO5
• Molecular Weight: 267.282
• Mol File: 318249-44-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-hydroxy-3-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-hydroxy-3-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (3R)-(318249-44-4)
• EPA Substance Registry System: Butanoic acid, 4-hydroxy-3-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (3R)-(318249-44-4)

Safety Data

• Hazardous Substances Data: 318249-44-4(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 123673-31-4 (R)-3-(benzyloxycarbonylamino)-4-hydroxybutanoic acid 
• 78663-07-7 N-(benzyloxycarbonyl)-D-aspartic acid 
• 67-56-1 methanol 
• 118399-28-3 (R)-4-benzyloxycarbonylamino-4,5-dihydro-2(3H)-furanone 
• 75443-62-8 benzyl N-[(3R)-2,5-dioxotetrahydrofuran-3-yl]carbamate 
• 162518-06-1 (R)-4-methyl-N-(5-oxotetrahydrofuran-3-yl)benzenesulfonamide 
• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 87219-29-2 benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate 

Downstream Products

• 1357575-04-2 (R)-methyl 3-amino-4-(phenylthio)butanoate, trifluoroacetic acid salt 
• 1357575-02-0 (R)-methyl 4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butanoate 
• 1357575-01-9 (R)-methyl 3-(benzyloxycarbonylamino)-4-(phenylthio)butanoate 
• 318249-47-7 Methylester of (R)-4-mesyloxy-3-(benzyloxycarbonylamino) Butanoic Acid 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.

Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

Synthesis of (R) and (S) -aminocarnitine and their derivatives starting from D- and L-aspartic acid

R or S aminocarnitine and their derivatives with formula (I) where Y is as described in the description, starting with aspartic acid with the same configuration as the aminocarnitine desired. This process has advantage in the type of reactants used, reduced volumes of solvents and the possibility of avoiding purification of intermediate products.