318276-72-1

Basic information

• Product Name: 6-bromocinnoline
• Synonyms: 6-bromocinnoline
• CAS NO: 318276-72-1
• Molecular Formula: C8H5BrN2
• Molecular Weight: 209.04
• Product Categories: Cinnoline Derivertives
• Mol File: 318276-72-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 129-130 °C
• Boiling Point: 325 °C at 760 mmHg
• Flash Point: 150.3 °C
• Appearance: /
• Density: 1.656 g/cm³
• Vapor Pressure: 0.00045mmHg at 25°C
• Refractive Index: 1.685
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.75±0.10(Predicted)
• CAS DataBase Reference: 6-bromocinnoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromocinnoline(318276-72-1)
• EPA Substance Registry System: 6-bromocinnoline(318276-72-1)

Safety Data

• Hazardous Substances Data: 318276-72-1(Hazardous Substances Data)

Usage

General Description

6-bromocinnoline is a chemical compound that belongs to the class of cinnoline derivatives. It is an organic compound containing a cinnoline core with a bromine atom attached at the 6-position. 6-bromocinnoline has several potential applications in the field of pharmaceuticals and material science due to its unique structural and chemical properties. 6-bromocinnoline is widely used as a building block in the synthesis of various biologically active compounds and as a precursor for the preparation of polymers and organic materials. Its versatility and reactivity make it a valuable chemical in the development of new drugs and advanced materials. Additionally, its bromine substituent confers specific electronic and steric properties that can be exploited in various chemical reactions and processes.

InChI:InChI=1/C8H5BrN2/c9-7-1-2-8-6(5-7)3-4-10-11-8/h1-5H

Upstream product

• 1129606-89-8 (Z)-1,4-dibromo-2-(2-bromovinyl)benzene 
• 1393462-55-9 diethyl 6-bromodihydrocinnoline-1,2-dicarboxylate 
• 876-88-0 6-bromocinnolin-4-ol 
• 106-40-1 4-bromo-aniline 
• 66416-72-6 4-bromo-2-iodoaniline 
• 29124-64-9 N-(2-acetyl-4-bromophenyl)acetamide 
• 29124-56-9 1-(2-amino-5-bromophenyl)ethanone 
• 68211-15-4 6-bromo-4-chlorocinnoline 
• 876-88-0 6-bromo-1H-cinnolin-4-one 
• 477909-64-1 1-(4-bromo-2-ethynylphenyl)-3,3-diethyltriazene 
• 552330-88-8 (6-bromocinnolin-4-yl)hydrazine 
• 551-93-9 2-aminoacetophenone 
• 5234-26-4 N-(2-acetylphenyl)acetamide 

Downstream Products

• 318276-74-3 6-carbomethoxycinnoline 
• 1201842-39-8 N-(2-chloro-5-(cinnolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 

Relevant articles and documents

Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity

Cinnoline is a potential pharmacophore which has rarely been reported for uses as PI3K inhibitors. In this study, a series of cinnoline derivatives were developed as PI3K inhibitors and evaluated for enzymatic and cellular activities. Most compounds displ

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors

A series of heteroaryl-pyridine containing inhibitors of Akt are reported. The synthesis and structure-activity relationships are discussed, leading to the discovery of a indazole-pyridine analogue (Ki = 0.16 nM). These compounds bind in the ATP binding site, are potent, ATP competitive, and reversible inhibitors of Akt activity. No selectivity amongst the Akt isoforms is observed for this analogue, but there is good selectivity against an panel of other kinases. It is least selective for other members of the AGC family of kinases but is nonetheless 40-fold selective for Akt over PKA. The compound shows cellular activity and significantly slows tumor growth in vivo.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.