31848-19-8 Usage
General Description
2-(prop-2-yn-1-yl)-2H-1,2-benzothiazin-3(4H)-one 1,1-dioxide, also known as PA-824, is a nitroimidazo-oxazine antibiotic that has shown promising activity against drug-resistant strains of tuberculosis. It works by disrupting the essential energy metabolism of Mycobacterium tuberculosis, the bacteria that causes tuberculosis, thereby inhibiting its growth. PA-824 has been studied extensively for its potential as a new treatment for tuberculosis, particularly multi-drug resistant and extensively drug-resistant strains, which are becoming increasingly prevalent and difficult to treat. Its unique mechanism of action and activity against drug-resistant strains make it a promising candidate for combating the global tuberculosis epidemic.
Check Digit Verification of cas no
The CAS Registry Mumber 31848-19-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,8,4 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 31848-19:
(7*3)+(6*1)+(5*8)+(4*4)+(3*8)+(2*1)+(1*9)=118
118 % 10 = 8
So 31848-19-8 is a valid CAS Registry Number.
31848-19-8Relevant articles and documents
New benzothiazines. 4. 1H 2,3 benzothiazin 4(3H) one 2,2 dioxide and 2H 1,2 benzothiazin 3(4H) one 1,1 dioxide nitrogen derivatives with central nervous system activity
Sianesi,Redaelli,Magistretti,Massarani
, p. 1133 - 1137 (2007/10/05)
The title compounds, bearing an alkyl, aminoalkyl, or aryl substituent on the nitrogen atom, were synthesized and tested for CNS activity; some N alkyl derivatives showed appreciable hypnotic and anticonvulsant properties in mice.
