3187-76-6

Basic information

• Product Name: cyclopropane-1,2-diamine
• Synonyms: cyclopropane-1,2-diamine;trans-Cyclopropane-1,2-diamine dihydrochloride;(1r.2r)-cyclopropane-1,2-diaMine dihydrochloride;1,2-Cyclopropanediamine;-Cyclopropane-1,2-diamine dihydrochloride
• CAS NO: 3187-76-6
• Molecular Formula: C₃H₈N₂*2ClH
• Molecular Weight: 108.57
• Mol File: 3187-76-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 133.6°Cat760mmHg
• Flash Point: 36.9°C
• Appearance: /
• Density: 1.054g/cm³
• Vapor Pressure: 8.4mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.94±0.40(Predicted)
• CAS DataBase Reference: cyclopropane-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopropane-1,2-diamine(3187-76-6)
• EPA Substance Registry System: cyclopropane-1,2-diamine(3187-76-6)

Safety Data

• Hazardous Substances Data: 3187-76-6(Hazardous Substances Data)

Usage

General Description

Cyclopropane-1,2-diamine, also known as ethylenediamine, is a chemical compound with the formula C3H8N2. It is a colorless, flammable liquid that is highly soluble in water. cyclopropane-1,2-diamine is used in the production of various chemicals, such as pesticides, fungicides, and pharmaceuticals. It is also commonly used as a chelating agent in the purification of sewage and industrial wastewater. Additionally, it can be found in certain household products, such as detergents and cleaning agents. Ethylenediamine is known to be a strong base and can react violently with oxidizing agents, making it important to handle with caution.

InChI:InChI=1/C3H8N2/c4-2-1-3(2)5/h2-3H,1,4-5H2

Upstream product

• 2177-51-7 cis-cyclopropane diisocyanate 
• 696-74-2 cis-1,2-cyclopropanedicarboxylic acid 
• 58616-95-8 trans-1,2-cyclopropanedicarboxylic acid 
• 1501-56-0 (trans)-cyclopropane-1,2-dicarbonyl dichloride 
• 68979-48-6 r-1,c-2-Cyclopropandicarbonsaeurediazid 

Downstream Products

• 3418-55-1 trans-N,N'-Bis(2,4,6-trimethylbenzyliden)-1,2-cyclopropandiamin 
• 3187-74-4 trans-N,N'-Bis(4-methylbenzyliden)-1,2-cyclopropandiamin 
• 733-41-5 trans-N,N'-dibenzylidene-1,2-cyclopropanediamine 
• 731-65-7 cis-2,3-Dihydro-2,3-diphenyl-1H-1,4-diazepine 
• 265987-99-3 (+/-)-(trans)-N-tert-butyloxycarbonyl-1,2-cyclopropanediamine 
• 87058-72-8 trans-N,N'-Bis(4-chlorbenzyliden)-1,2-cyclopropandiamin 
• 87058-73-9 trans-N,N'-Bis(3,5-dimethylbenzyliden)-1,2-cyclopropandiamin 
• 87058-74-0 trans-N,N'-Bis<3,5-di(1,1-dimethylethyl)benzyliden>-1,2-cyclopropandiamin 
• 87058-77-3 cis-2,3-Dihydro-2,3-bis(pentadeuteriophenyl)-1H-1,4-diazepin 

Relevant articles and documents

ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS

Provided are alkylboronic acids as arginase inhibitors represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, tautomer, or prodrug thereof and a pharmaceutical composition comprising said compounds.

Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors

A series of bisnaphthalimide derivatives were synthesized and evaluated for growth-inhibitory property against HT-29 human colon carcinoma. The N,N′-bis[2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-benz[de]-isoquinolin- 2-yl)]propane-2-ethanediamine (9) and the N,N′-Bis[2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-benz[de]-isoquinolin- 2-yl)]butylaminoethyl]-2-propanediamine (12) derivatives emerged as the most potent compounds of this series. Molecular modelling studies indicated that the high potency of 12, the most cytotoxic compound of the whole series, could be due to larger number of intermolecular interactions and to the best position of the naphthalimido rings, which favours π-π stacking interactions with purine and pyrimidine bases in the DNA active site. Moreover, 12 was designed as a DNA topoisomerase II poison and biochemical studies showed its effect on human DNA topoisomerase II. We then selected the compounds with a significant cytotoxicity for apoptosis assay. Derivative 9 was able to induce significantly apoptosis (40%) at 0.1 μM concentration, and we demonstrated that the effect on apoptosis in HT-29 cells is mediated by caspases activation.

Cyclopropanediamines, 4. - Synthesis and 1H-NMR Spectra of Pure Diastereomers of 1,2-Cyclopropanediamines and 1,2-Cyclopropanediammonium Dibromides

The efficient preparation of pure diastereomers of N,N'-(1,2-cyclopropanediyl)diurethanes 16-18 and -diammonium dibromides 4, 19, and 20 is reported.Curtius rearrangement of cis- and trans-1,2-cyclopropanedicarboxylic dihydrazides 14 yields di(O-benzyl) d