31969-10-5

Basic information

• Product Name: 4(1H)-Pteridinone, 2-amino-5,6,7,8-tetrahydro-6-(hydroxymethyl)-
• CAS NO: 31969-10-5
• Molecular Formula: C7H11N5O2
• Molecular Weight: 197.197
• Mol File: 31969-10-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4(1H)-Pteridinone, 2-amino-5,6,7,8-tetrahydro-6-(hydroxymethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pteridinone, 2-amino-5,6,7,8-tetrahydro-6-(hydroxymethyl)-(31969-10-5)
• EPA Substance Registry System: 4(1H)-Pteridinone, 2-amino-5,6,7,8-tetrahydro-6-(hydroxymethyl)-(31969-10-5)

Safety Data

• Hazardous Substances Data: 31969-10-5(Hazardous Substances Data)

Upstream product

• 712-29-8 6-(hydroxymethyl)pterin 

Downstream Products

• 325708-61-0 5,6,7,8-tetrahydro-6-(hydroxymethyl)-5-{[2-(4-nitrophenyl)ethoxy]carbonyl}pterin 
• 325708-78-9 2-(4-nitrophenyl)ethyl 6-{[3-(4-benzoylphenyl)-1-oxopropoxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate 
• 325708-89-2 2-(4-nitrophenyl)ethyl 2-amino-6-{[3-(4-benzoylphenyl)-1-oxopropoxy]methyl}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate 
• 325708-82-5 2-(4-nitrophenyl)ethyl 2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxo-6-[({4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoyl}oxy)methyl]pteridine-5-carboxylate 
• 325708-72-3 2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate 
• 325708-69-8 N²-[(dimethylamino)methylene]-5,6,7,8-tetrahydro-6-(hydroxymethyl)-5-{[2-(4-nitrophenyl)ethoxy]carbonyl}pterin 

Relevant articles and documents

Pteridines. Part CXI. Pteridine-based photoaffinity probes for nitric oxide synthase and aromatic amino acid hydroxylases

Various 6-substituted pteridines and 5,6,7,8-tetrahydropterins carrying photolabile functions at the side chain (see 7, 20-22, 34-36, 38, and 39) as well as at the 5-position (see 27-29) were synthesized from pterin and from 6-phenylpterin (1) and 6-(hydroxymethyl)pterin (10). Attachment of the photoaffinity labels via ester bonds required a special protecting-group strategy based upon acid-labile (see 30-33) and β-eliminating blocking groups (see 17-19). The 6-(4-azidophenyl)pterin (7) was obtained from 6-phenylpterin (1) via intermediates 2 and 4-6, due to the low solubility of simple pterins in general. The pteridine derivatives 21, 22, 25, 26, 28, 29, 32, 33, 35, 36, 38, and 39 were screened as inhibitors of neuronal (type I) NO synthase (see Table) from porcine cerebellum. of which 22, 35, 36, and 38 showed interesting inhibitory activity with similar potency and effectiveness.

Determination of Pterins in Biological Samples by Liquid Chromatography/Electrochemistry with a Dual-Electrode Detector

The pterins are a family of compounds that are currently of great interest in medicine and biology.Biopterin, in its reduced form, serves as the cofactor to the enzyme which catalyze the rate-limiting reactions in the biosynthesis of the catecholamines and serotonin.As such, it may serve a role in the regulation of the neurotransmitters.Abnormal pterin concentrations have been observed in the urine and serum of patiens with several diseases.No currently available analytical method is totally satisfactory for the determination of pterins in biological samples.They lack either specificity or the ability to detect both the oxidzed and reduced forms of the pterins.Liquid chromatography/electrochemistry (LCEC) using a dual-electrode detector can overcome both of these problems.A method has been developed that is capable of determining several pterin species and their various oxidation states in biological samples.The dual-electrode detector used in a parallel-adjacent configuration is also capable of enhancing peak identity assignments and selectively determining easily oxidized compounds in the presence of harder to oxidize compounds.