3198-97-8Relevant articles and documents
Novel pyrazole derivatives via ring transformations: Anti-inflammatory and antifungal activity studies
Kattimani, Pramod P.,Kamble, Ravindra R.,Nesaragi, Aravind R.,Kariduraganavar, Mahadevappa Y.,Joshi, Shrinivas D.,Dodamani, Suneel S.,Jalalpure, Sunil S.
, p. 3125 - 3140 (2021/09/11)
In this paper, the synthesis of novel pyrazoles and their in vitro anti-inflammatory and in-vitro antifungal assay have been reported. These compounds were docked into the inducible nitric oxide synthase (iNOS) oxygenase dimer. The compounds 3c, 7a, 7c, 8
Reaction of 4-Hydroxy-5-oximino-3-thiophenecarboxylates with Hydrazines. Formation of Pyrazolylthiohydroxamic Acids
Robey,Alt,Van Meter
, p. 413 - 428 (2007/10/03)
The reactions of 4-hydroxy-5-oximino-3-thiophenecarboxylates with hydrazine and substituted hydrazines have been investigated. The products of the reactions have been shown to be pyrazole-3- or 5-thiohydroxamic acids rather than the hydrazones previously described by Benary and Silberstrom. Two alternate mechanisms are proposed which account for the regiochemical outcome. The structures of the pyrazole-3- and 5-thiohydroxamic acids and corresponding nitriles have been proven by independent synthesis, comparison to known compounds, and by proton and carbon magnetic resonance and long range HETCOR experiments.
