31991-78-3

Basic information

• Product Name: N-(4-benzamidobutyl)benzamide
• Synonyms: N-(4-benzamidobutyl)benzamide
• CAS NO: 31991-78-3
• Molecular Formula: C₁₈H₂₀N₂O₂
• Molecular Weight: 296.3636
• EINECS: -0
• Mol File: 31991-78-3.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 596.9°Cat760mmHg
• Flash Point: 225.1°C
• Appearance: /
• Density: 1.122g/cm³
• CAS DataBase Reference: N-(4-benzamidobutyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-benzamidobutyl)benzamide(31991-78-3)
• EPA Substance Registry System: N-(4-benzamidobutyl)benzamide(31991-78-3)

Safety Data

• Hazardous Substances Data: 31991-78-3(Hazardous Substances Data)

Usage

General Description

N-(4-benzamidobutyl)benzamide is a chemical compound with the molecular formula C22H23N3O2. It is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and chemicals. N-(4-benzamidobutyl)benzamide is a benzamide derivative and contains a benzene ring attached to a 4-benzamidobutyl group. It has potential applications in the fields of medicine and drug development due to its ability to interact with biological systems and receptors. N-(4-benzamidobutyl)benzamide may also have use in research and development of new pharmaceuticals and therapeutic agents.

Upstream product

• 7646-66-4 N-benzoylaziridine 
• 110-60-1 1,4-diaminobutane 
• 65-85-0 benzoic acid 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 10364-94-0 1-benzoylimidazole 
• 333-93-7 putrescine dihydrochloride 
• 23405-15-4 benzoic acid N-hydroxysuccinimide ester 
• 43218-39-9 5-benzoylamino-valeryl chloride 
• 100253-61-0 5-benzoylamino-valeric acid amide 
• 15647-47-9 5-benzoylaminopentanoic acid 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 120-12-7 anthracene 

Downstream Products

• 110-52-1 1,4-dibromo-butane 
• 100-47-0 benzonitrile 
• 110-56-5 1,4-dichlorobutane 
• 93-58-3 benzoic acid methyl ester 
• 6345-94-4 N-(4-chlorobutyl)benzamide 
• 16012-03-6 N,N'-Dimethyl-N,N'-dibenzoyl-1,4-diaminobutan 
• 32039-04-6 N-Benzoyl-N'-benzyl-putrescin 
• 31719-05-8 N,N'-dibenzylbutane-1,4-diamine 
• 110-60-1 1,4-diaminobutane 
• 5692-23-9 N-(4-aminobutyl)benzamide 

Relevant articles and documents

One-step synthesis of dicarboxamides through Pd-catalysed aminocarbonylation with diamines as N-nucleophiles

An efficient one-step synthetic strategy was used to prepare a set of dicarboxamides through palladium-catalysed aminocarbonylation of iodoalkenyl and iodoaryl compounds, with use of various alkyl- and aryldiamines as N-nucleophiles. The isolated yields of the dicarboxamides depended significantly on the iodo substrate and diamine structures, as well as on the reaction conditions, the best one (ca. 70%) being achieved with 1-iodocyclohexene as substrate and 1,4-diaminobutane as nucleophile, at 100°C and 30 bar of CO. When iodobenzene was used as model aryl halide, the highest yield of the target dibenzamides (ca. 65%) was obtained with 1,4-diaminobenzene as coupling amine, at 100°C and 10 bar of CO. Preliminary studies on their in vitro cytotoxicity against human lung carcinoma A549 cells showed N,N′(butane-1,4-diyl)dibenzamide and androst-16-ene-based dicarboxamides to be the most efficient cytotoxic agents, with IC50 values of approximately 40 μM.

Anodic oxidation of bisamides from diaminoalkanes by constant current electrolysis

In general, bisamides derived from diamines and involving 3 and 4 methylene groups as spacers between the two amide functionalities behave similar to monoamides upon anodic oxidation in methanol/LiClO4 because both types undergo majorly mono- and dimethoxylations at the α-position to the N atom. However, in cases where the spacer contains two methylene groups only the anodic process leads mostly to CH2-CH2 bond cleavage to afford products of type RCONHCH2OCH3. Moreover, upon replacing LiClO4 with Et4NBF4 an additional fragmentation type of product was generated from the latter amides, namely RCONHCHO. Also, the anodic process was found to be more efficient with C felt as the anode, and in a mixture of 1:1 methanol/acetonitrile co-solvents.

CDI-mediated monoacylation of symmetrical diamines and selective acylation of primary amines of unsymmetrical diamines

A highly efficient and green protocol for monoacylation of symmetrical diamines and chemoselective acylation of primary amines of unsymmetrical diamines has been developed.