3201-29-4

Basic information

• Product Name: 2,5-Dimethyl-1H-pyrazol-3(2H)-one
• Synonyms: 1,3-dimethyl-5-oxo-1,2-diazacyclopent-3-ene;2,5-dimethyl-1,2-dihydro-pyrazol-3-one;2,5-dimethyl-1H-pyrazol-3(2H)-one;1,3-dimethyl-pyrazol-5-one;1,2-dihydro-2,5-dimethylpyrazol-3-one;2,3-Dihydro-2,5-dimethyl-1H-pyrazol-3-on
• CAS NO: 3201-29-4
• Molecular Formula: C5H8N2O
• Molecular Weight: 112.131
• Mol File: 3201-29-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,5-Dimethyl-1H-pyrazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethyl-1H-pyrazol-3(2H)-one(3201-29-4)
• EPA Substance Registry System: 2,5-Dimethyl-1H-pyrazol-3(2H)-one(3201-29-4)

Safety Data

• Hazardous Substances Data: 3201-29-4(Hazardous Substances Data)

Usage

Physical form

white crystalline solid

Melting point

108-112°C

Solubility

soluble in organic solvents (e.g. ethanol, acetone, ethyl acetate), insoluble in water

Uses

production of pharmaceuticals and agrochemicals, synthesis of other organic compounds, chelating agent in metal ion extraction and purification processes.

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 60-34-4 methylhydrazine 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 141-97-9 ethyl acetoacetate 
• 302-15-8 methylhydrazine sulfuric acid 
• 98553-54-9 3-(2-methyl-semicarbazono)-butyric acid ethyl ester 

Downstream Products

• 58010-98-3 4-(2,4-dichlorobenzoyl)-1,3-dimethyl-5-hydroxypyrazole 
• 58011-01-1 1,3-dimethyl-4-(4-chlorobenzoyl)-5-hydroxypyrazole 
• 37704-89-5 (1,3-dimethyl-5-hydroxy-1H-pyrazol-4-yl)phenylmethanone 
• 37704-91-9 2,5-dimethyl-4-(4-nitro-benzoyl)-1,2-dihydro-pyrazol-3-one 
• 62031-13-4 5-(4-chloro-benzoyloxy)-1,3-dimethyl-1H-pyrazole 
• 27006-76-4 5-chloro-4-formyl-1,3-dimethylpyrazole 
• 1177283-50-9 (5-methoxy-1,3-dimethyl-1H-pyrazol-4-yl)methanamine 
• 96286-02-1 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonitrile 
• 78431-25-1 1,3-dimethyl-5-methylthio-4-phenyldiazenyl-1,2-diazacyclopenta-2,4-diene 
• 78431-23-9 methyl-azothiopyrine (1,3-dimethyl-5-mercapto-4-phenyldiazenyl-1,2-diazacyclopenta-2,4-diene) 
• 78431-21-7 5-chloro-1,3-dimethyl-4-phenyldiazenyl-1,2-diazacyclopenta-2,4-diene 
• 10250-58-5 1,3-dimethyl-5-phenyl-1H-pyrazole 
• 81649-68-5 1,2-dihydro-2,5-dimethyl-4-nitropyrazol-3-one 
• 78431-20-6 1,3-dimethyl-5-oxo-4-phenyldiazenyl-1,2-diazacyclopent-3-ene 

Relevant articles and documents

Containing substituted 1, 3, 4-thiadiazole sulfide pyrazole amide and pyrazole imine derivatives and preparation method and application

The invention discloses pyrazole amide and pyrazole imine derivatives containing substituted 1, 3, 4-thiadiazole thioether as well as a preparation method and an application of the derivatives. The compounds have the structures as shown in formulae (I) and (II). The preparation method comprises the following steps: by taking substituted hydrazine as an initial raw material, carrying out closed loop, chlorine formylation, oxidation and chloro reaction to obtain pyrazole acyl chloride; carrying out a reaction on 2-amino-5-mercapto-1, 3, 4-thiadiazole and substituted benzyl chloride to obtain 2-amino-5-substituted 1, 3, 4-thiadiazole thioether; and then, carrying out a substitution reaction on 2-amino-5-substituted 1, 3, 4-thiadiazole thioether and substituted pyrazole acyl chloride to obtain the pyrazole amide compound (I) containing substituted 1, 3, 4-thiadiazole thioether; by taking substituted hydrazine as an initial raw material, carrying out closed loop and chlorine formylation to obtain pyrazole aldehyde; carrying out an additive elimination reaction on pyrazole aldehyde and 2-amino-5-mercapto-1, 3, 4-thiadiazole under a backflow condition of anhydrous ethanol to obtain 2-substituted pyrazole imidogen-5-mercapto-1, 3, 4-thiadiazole; and then carrying out a reaction on 2-substituted pyrazole imidogen-5-mercapto-1, 3, 4-thiadiazole and substituted benzyl chloride to generate the pyrazole imine compound (II) containing substituted 1, 3, 4-thiadiazole thioether. The compounds disclosed by the invention have a good inhibiting effect on tobacco mosaic virus and can be used for preparing anti-plant virus drugs.

SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS

The present invention relates to substituted benzene compounds and bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Mechanisms of Heterocycle Ring Formation. Part 5. A Carbon-13 Nuclear Magnetic Resonance Study of Pyrazolinone Synthesis by the Reaction of β-Ketoesters with Substituted Hydrazines

The 16 reactions between each of four hydrazines and four β-ketoesters have been followed by 13C n.m.r. spectroscopy.Peaks were assigned to starting materials, intermediates, and products, and reaction mechanisms determined and rationalized.Most rections proceed by attack of the least hindered hydrazine nitrogen atom on the keto carbon group of the ketoester.Relative rates of nucleophilic attack determine the build-up of intermediate and in some cases the nature of the products formed.