3213-94-3

Basic information

• Product Name: 1H-1,2,4-Triazole, 3-methyl-5-(4-methylphenyl)-
• CAS NO: 3213-94-3
• Molecular Formula: C10H11N3
• Molecular Weight: 173.217
• Mol File: 3213-94-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazole, 3-methyl-5-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole, 3-methyl-5-(4-methylphenyl)-(3213-94-3)
• EPA Substance Registry System: 1H-1,2,4-Triazole, 3-methyl-5-(4-methylphenyl)-(3213-94-3)

Safety Data

• Hazardous Substances Data: 3213-94-3(Hazardous Substances Data)

Usage

Derivative of 1,2,4-Triazole

Indicates that the compound is derived from the parent compound 1,2,4-triazole, which is a heterocyclic organic compound.

Industrial and Chemical Processes

The compound is used in various industrial and chemical processes, such as pharmaceutical and agricultural chemical intermediates, and as a reagent in organic synthesis.

Pharmaceutical Intermediate

It serves as a building block or precursor in the synthesis of pharmaceutical compounds.

Agricultural Chemical Intermediate

It is used in the synthesis of agrochemicals, such as pesticides and fertilizers.

Reagent in Organic Synthesis

The compound acts as a reagent, facilitating specific chemical reactions in organic synthesis.

Potential Biological Activities

The compound has been studied for its possible biological activities, such as anti-inflammatory, antifungal, and anticancer properties.

Anti-inflammatory

It may help reduce inflammation in the body.

Antifungal

It may exhibit properties that inhibit the growth of fungi.

Anticancer

It has been investigated for its potential to inhibit or prevent the growth of cancer cells.

Low Toxicity

The compound is considered to have low toxicity, making it relatively safe to handle and use.

Safety Protocols

It is generally considered safe when handled and used according to standard safety protocols, such as wearing appropriate personal protective equipment and following proper disposal procedures.

Upstream product

• 124-42-5 acetamidine hydrochloride 
• 6326-27-8 p-methylbenzamidine hydrochloride 
• 210179-03-6 4-methyl-benzoic acid N'-(1-imino-ethyl)-hydrazide 
• 1314991-79-1 4-methyl-benzoic acid (1-imino-ethyl)hydrazide 
• 7170-01-6 3-methyl-1H-[1,2,4]triazole 
• 104-87-0 4-methyl-benzaldehyde 
• 19227-13-5 p-toluamidoxime 

Downstream Products

• 860025-98-5 [1,1-dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)propyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

TBHP/TBAI–Mediated simple and efficient synthesis of 3,5-disubstituted and 1,3,5-trisubstituted 1H-1,2,4-triazoles via oxidative decarbonylation of aromatic aldehydes and testing for antibacterial activities

The author has developed a simple, efficient and eco–friendly convenient general method for synthesis of 3,5–disubstituted–1,2,4–triazoles and 1,3,5–trisubstituted–1,2,4–triazoles from 3–monosubstituted–1,2,4–triazoles and 1,3–disubstituted–1,2,4–triazoles respectively using tetrabutylammonium iodide (TBAI) as catalyst and TBHP as oxidant under mid reaction conditions. This method provides structurally diverse 3,5–disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles in good to excellent yields. 3,5–Disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles derivatives are biologically and pharmaceutically active molecules, and therefore, this protocol could be of wide applications in medicinal chemistry and organic chemistry.

Copper-catalyzed synthesis of 1,2,4-triazoles via sequential coupling and aerobic oxidative dehydrogenation of amidines

A convenient, efficient, and practical copper-catalyzed one-pot method for the synthesis of 1,2,4-triazoles has been developed via reactions of amidines. The procedure underwent sequential base-promoted intermolecular coupling (nucleophilic substitution) between two amidines and intramolecular aerobic oxidative dehydrogenation, and the inexpensive, convenient, and efficient method for the synthesis of 1,2,4-triazoles will attract much attention in academic and industrial research. Georg Thieme Verlag Stuttgart · New York.

SMALL MOLECULE MODULATORS OF CELL ADHESION

Compounds, particularly compounds having activity as modulators of cadherin-mediated cell adhesion having the following structure: or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein R1, R2, R3,