321371-29-3

Basic information

• Product Name: 4-Thiazolecarboxylicacid,2-(chloromethyl)-,methylester(9CI)
• Synonyms: 4-Thiazolecarboxylicacid,2-(chloromethyl)-,methylester(9CI);Methyl 2-(chloromethyl)thiazole-4-carboxylate
• CAS NO: 321371-29-3
• Molecular Formula: C6H6ClNO2S
• Molecular Weight: 191.63
• Product Categories: THIAZOLE
• Mol File: 321371-29-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 261.2°Cat760mmHg
• Flash Point: 111.8°C
• Appearance: /
• Density: 1.391g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.48±0.10(Predicted)
• CAS DataBase Reference: 4-Thiazolecarboxylicacid,2-(chloromethyl)-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolecarboxylicacid,2-(chloromethyl)-,methylester(9CI)(321371-29-3)
• EPA Substance Registry System: 4-Thiazolecarboxylicacid,2-(chloromethyl)-,methylester(9CI)(321371-29-3)

Safety Data

• Hazardous Substances Data: 321371-29-3(Hazardous Substances Data)

Usage

General Description

4-Thiazolecarboxylic acid, 2-(chloromethyl)-, methyl ester (9CI) is a chemical compound that belongs to the family of thiazole carboxylic acids. It is a methyl ester derivative of 4-thiazolecarboxylic acid, and contains a chloromethyl group. Thiazole carboxylic acids are commonly used in the synthesis of pharmaceuticals and agrochemicals. The presence of the chloromethyl group in this compound may make it useful as a building block in organic synthesis, particularly in the preparation of complex molecules. Additionally, the compound may have potential applications in the development of new drugs or as a research tool in chemical biology. Overall, 4-Thiazolecarboxylic acid, 2-(chloromethyl)-, methyl ester (9CI) is a versatile chemical that has potential utility in various fields of chemistry and drug discovery.

Upstream product

• 321371-28-2 methyl 2-(dichloromethyl)-4,5-dihydro-1,3-thiazole-4-carboxylate 
• 124-41-4 sodium methylate 

Relevant articles and documents

Incorporation of heterocycles into the backbone of peptoids to generate diverse peptoid-inspired one bead one compound libraries

Combinatorial libraries of peptoids (oligo-N-substituted glycines) have proven to be useful sources of protein ligands. Each unit of the peptoid oligomer is derived from 2-haloacetic acid and a primary amine. To increase the chemical diversity available in peptoid libraries, we demonstrate here that heterocyclic halomethyl carboxylic acids can be employed as backbone building blocks in the synthesis of peptoid-based oligomers. Optimized conditions are reported that allow the creation of large, high quality combinatorial libraries containing these units.

ARYL DICARBOXAMIDES

The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycernia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholes-terolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of aryl dicarboxamides of formula (I) to modulate, notably to inhibit the activity of PTPs. A is an airninocarbonyl moiety; Cy is an aryl, heteroaryl, aryl-heteroaryl, heteroaryl-aryl, aryl-aryl, cycloalkyl or heterocycle group; n is either 0 or 1; R1 and R2 are independently from each other is selected from the group consisting of hydrogen or C1-C6-alkyl; R4 and R5 are each independently from each other selected from the group consisting of H, hydroxy, C1-C6 alkyl, carboxy, C1-C6 alkoxy, C1-C3 alkyl carboxy, C2-C3 alkenyl carboxy, C2-C3 alkynyl carboxy, amino or R4 and R5 may form an unsaturated or saturated heterocyclic ring, whereby at least one of R4 or R5 is not a hydrogen or C1-C6 alkyl.