321596-55-8

Basic information

• Product Name: 4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester
• Synonyms: 4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester;Methyl 4,6-dibroMo-3-hydroxypicolinate;2-Pyridinecarboxylic acid, 4,6-dibroMo-3-hydroxy-, Methyl ester
• CAS NO: 321596-55-8
• Molecular Formula: C₇H₅Br₂NO₃
• Molecular Weight: 311
• EINECS: 604-604-1
• Mol File: 321596-55-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 389.3±37.0 °C(Predicted)
• Appearance: /
• Density: 2.054
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.91±0.10(Predicted)
• CAS DataBase Reference: 4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester(321596-55-8)
• EPA Substance Registry System: 4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester(321596-55-8)

Safety Data

• Hazardous Substances Data: 321596-55-8(Hazardous Substances Data)

Usage

General Description

4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester is a chemical compound that is commonly used in organic synthesis and medicinal chemistry. It is a methyl ester derivative of 4,6-dibromo-3-hydroxypyridine-2-carboxylic acid, containing two bromine atoms, a hydroxyl group, and a carboxylic acid. 4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester is often used as a building block for the synthesis of various pharmaceuticals and drug candidates, due to its potential as a bioactive molecule. It has also been studied for its antifungal and antibacterial properties. Additionally, 4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester has been investigated for its potential use in the development of new agrochemicals and crop protection products. Overall, this compound has versatile applications and is of interest in multiple fields of research and development.

Upstream product

• 869556-74-1 methyl 2-(furan-2-yl)-2-(methoxyimino)acetate 
• 65866-86-6 2-(furan-2-yl)-2-(methoxyimino)acetic acid 
• 1467-70-5 furan-2-yl-oxo-acetic acid 
• 70946-43-9 methyl 2-amino-2-(furan-2-yl)acetate 
• 113452-72-5 (RS)-methyl 2-(benzyloxycarbonylamino)-2-(furan-2-yl)acetate 
• 62733-99-7 methyl 3-hydroxypicolinate 
• 874-24-8 3-hydroxypyridine-2-carboxylic acid 

Downstream Products

• 1961312-55-9 Adavelt 
• 210300-09-7 3-hydroxy-4-methoxy-pyridine-2-carboxylic acid 
• 321596-57-0 6-BROMO-3-BENZYLOXY-4-METHOXYPYRIDINE-2-CARBONYL CHLORIDE 
• 321596-54-7 6-BROMO-3-BENZYLOXY-4-METHOXYPYRIDINE-2-CARBOXYLIC ACID 
• 321596-56-9 METHYL 4,6-DIBROMO-3-BENZYLOXYPYRIDINE-2-CARBOXYLATE 
• 1342906-72-2 methyl 3-benzyloxy-4-bromo-6-methylpicolinate 

Relevant articles and documents

NOVEL ISOINDOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed are a novel isoindoline derivative, a pharmaceutical composition and use thereof. The compound of formula I, or the pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer, isotopic compound, metabolite or prodrug thereof disclosed in the invention can regulate the generation and/or activity of PDE4 and/or TNF-α so as to effectively treat cancer and inflammatory diseases.

Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

Despite major advances in the β-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the class D (OXA) enzymes

TRICYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS

The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.