32223-65-7

Basic information

• Product Name: Benzene, 1-isocyanato-2-(pentyloxy)-
• CAS NO: 32223-65-7
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol File: 32223-65-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1-isocyanato-2-(pentyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-isocyanato-2-(pentyloxy)-(32223-65-7)
• EPA Substance Registry System: Benzene, 1-isocyanato-2-(pentyloxy)-(32223-65-7)

Safety Data

• Hazardous Substances Data: 32223-65-7(Hazardous Substances Data)

Upstream product

• 55792-54-6 acetic acid-(2-pentyloxy-anilide) 
• 95-55-6 2-amino-phenol 
• 75-44-5 phosgene 
• 52464-51-4 2-(pentyloxy)aniline 
• 614-80-2 2-(acetylamino)phenol 
• 2200-82-0 2-(pentyloxy)benzoic acid 
• 7091-14-7 2-pentyloxybenzaldehyde 

Downstream Products

• 112922-95-9 (2-Pentyloxy-phenyl)-carbamic acid 2-morpholin-4-yl-ethyl ester; hydrochloride 
• 87409-03-8 (2-Pentyloxy-phenyl)-carbamic acid 1-diethylaminomethyl-2-piperidin-1-yl-ethyl ester; hydrochloride 
• 143503-45-1 (2-Pentyloxy-phenyl)-carbamic acid 2-azepan-1-yl-1-propoxymethyl-ethyl ester 
• 105376-91-8 (2-Pentyloxy-phenyl)-carbamic acid 1-diethylaminomethyl-2-pyrrolidin-1-yl-ethyl ester; compound with oxalic acid 
• 1362626-41-2 C₂₀H₂₆N₂O₂ 
• 87417-61-6 (2-Pentyloxy-phenyl)-carbamic acid 2-azepan-1-yl-1-diethylaminomethyl-ethyl ester; hydrochloride 
• 105920-34-1 (2-Pentyloxy-phenyl)-carbamic acid 1-propoxymethyl-2-pyrrolidin-1-yl-ethyl ester 
• 105920-50-1 (2-Pentyloxy-phenyl)-carbamic acid 2-piperidin-1-yl-1-propoxymethyl-ethyl ester 

Relevant articles and documents

Determination of critical micellar concentration of homologous 2-alkoxyphenylcarbamoyloxyethyl-morpholinium chlorides

The critical micellar concentrations of selected alkyloxy homologues of local anesthetic 4-(2-[(2-alkoxyphenyl)carbamoyl]oxy ethyl)morpholin-4-ium chloride with nc = 2, 4, 5, 6, 7, 8, and 9 carbons in alkyloxy tail were determined by absorption spectroscopy in the UV–vis spectral region with the use of a pyrene probe. Within the homologous series of the studied amphiphilic compounds, the ln(cmc) was observed to be dependent linearly on the number of carbon atoms nc in the hydrophobic tail: ln(cmc) = 0.705–0.966 nc. The Gibbs free energy, necessary for the transfer of the methylene group of the alkoxy chain from the water phase into the inner part of the micelle at the temperature of 25?C and pH ≈ 4.5–5.0, was found to be ?2.39 kJ/mol. The experimentally determined cmc values showed good correlations with the predicted values of the bulkiness of the alkoxy tail expressed as the molar volume of substituent R, as well as with the surface tension of the compounds.

Discovery and structural modification of 1-phenyl-3-(1-phenylethyl)urea derivatives as inhibitors of complement

A series of 1-phenyl-3-(1-phenylethyl)urea derivatives were identified as novel and potent complement inhibitors through structural modification of the original compound from high-throughput screening. Various analogues (7 and 13-15) were synthesized and identified as complement inhibitors, with the introduction of a five- or six-carbon chain (7c, 7d, 7k, 7l, and 7o) greatly improving their activity. Optimized compound 7l has an excellent inhibition activity with IC50 values as low as 13 nM. We demonstrated that the compound 7l inhibited C9 deposition through the classical, the lectin, and the alternative pathways but had no influence on C3 and C4 depositions.