3223-77-6

Basic information

• Product Name: 2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE
• Synonyms: 2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE;AKOS B020637;ASISCHEM A49644;ART-CHEM-BB B020637
• CAS NO: 3223-77-6
• Molecular Formula: C₉H₉ClN₂O₄
• Molecular Weight: 244.63
• Mol File: 3223-77-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 101 °C(Solv: ethanol (64-17-5))
• Boiling Point: 463.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.441±0.06 g/cm3(Predicted)
• PKA: 11.01±0.70(Predicted)
• CAS DataBase Reference: 2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE(3223-77-6)
• EPA Substance Registry System: 2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE(3223-77-6)

Safety Data

• Hazardous Substances Data: 3223-77-6(Hazardous Substances Data)

Usage

General Description

2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE is a chemical compound with the molecular formula C9H8ClN3O4. It is a chlorinated acetamide derivative with a phenyl group substituted with a methoxy and nitro group. 2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE is used in various chemical and pharmaceutical applications, including as a building block in the synthesis of other organic compounds. It may also have biological and pharmacological properties, although further research is needed to fully understand its potential uses and effects.

Upstream product

• 79-04-9 chloroacetyl chloride 
• 96-96-8 4-methoxy-2-nitroaniline 
• 64-17-5 ethanol 
• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 
• 104-94-9 4-methoxy-aniline 
• 64-19-7 acetic acid 

Downstream Products

• 1206903-37-8 C₃₅H₅₈N₆O₁₀ 
• 2574-01-8 piperidino-acetic acid-(2-amino-4-methoxy-anilide) 
• 5473-00-7 4-methoxy-2,3-dinitro-aniline 
• 96-96-8 4-methoxy-2-nitroaniline 
• 97457-75-5 3-Hydroxy-benzo[b]thiophene-2-carboxylic acid (4-methoxy-2-nitro-phenyl)-amide 
• 861341-80-2 chloro-acetic acid-(4-methoxy-2,3-dinitro-anilide) 
• 861797-58-2 chloro-acetic acid-(4-methoxy-2,5-dinitro-anilide) 
• 2718-19-6 piperidino-acetic acid-(4-methoxy-2-nitro-anilide) 

Relevant articles and documents

Synthesis, molecular docking and α-glucosidase inhibition of 2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-N-arylacetamides

A novel series of 2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-N-arylacetamides 5a–5q have been synthesized and evaluated for their α-glucosidase inhibitory activity. All newly synthesized compounds exhibited potent α-glucosidase inhibitory activity in the range of IC50?=?12.46?±?0.13–72.68?±?0.20?μM, when compared to the standard drug acarbose (IC50?=?817.38?±?6.27?μM). Among the series, compound 5j (12.46?±?0.13?μM) with strong electron-withdrawing nitro group on the arylacetamide moiety was identified as the most potent inhibitor of α-glucosidase. Molecular docking study was carried out to explore the binding interactions of these compounds with α-glucosidase. Our study identifies a novel series of potent α-glucosidase inhibitors for further investigation.

Activities of 2-carboxanilido 3-hydroxybenzo[b]thiophens against molluscs Biomphalaria

The title compounds are shown to be nearly as active against molluscs as Niclosamide when they are either dihalogenated or monohalogenated and mononitrated on the benzene ring.