322474-08-8 Usage
General Description
1-(3-Hydroxy-4-Methoxyphenyl)-2-Nitropropene is a chemical compound with the molecular formula C10H11NO4. It is also known by the synonym p-Hydroxy-β-nitrostyrene. This chemical is a yellow crystalline solid that is commonly used in organic synthesis and as a building block in the production of various pharmaceuticals and agrochemicals. It is notable for its nitro group, which gives it reactive properties and makes it useful in a variety of chemical reactions. Additionally, the presence of the hydroxy and methoxy groups on the phenyl ring provide the compound with additional functionality and potential for use in specialized applications in the chemical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 322474-08-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,2,4,7 and 4 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 322474-08:
(8*3)+(7*2)+(6*2)+(5*4)+(4*7)+(3*4)+(2*0)+(1*8)=118
118 % 10 = 8
So 322474-08-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO4/c1-7(11(13)14)5-8-3-4-10(15-2)9(12)6-8/h3-6,12H,1-2H3/b7-5+
322474-08-8Relevant articles and documents
Exploring nitrostyrene as a scaffold for a new class a of monoamine oxidase inhibitors
Reis, Joana,Oliveira, Catarina,Milhazes, Nuno,Vi?a, Dolores,Borges, Fernanda
, p. 958 - 961 (2013/02/23)
With the ultimate purpose of finding out the structural features that are relevant for MAO inhibitory activity and selectivity towards MAO-B isoform, a series of compounds encompassing a β-nitrostyrene moiety was designed and the in vitro inhibitory activity was evaluated. In the present work, we report the synthesis and the pharmacological evaluation of a series of functionalized derivatives of β-methyl-β-nitrostyrene with distinct substitution patterns in the phenyl ring, namely hydroxyl, methoxy, benzyloxy and methylenedioxy. All the studied compounds were substituted in meta and para positions of the phenyl ring related to the nitrovinyl side chain. The synthesized compounds were evaluated towards both human MAO isoforms, displaying some of them activities in the low micromolar range. Particularly compound 6 (a methylenedioxy derivative) exhibits high potency and selectivity towards MAO-B.
