323580-68-3

Basic information

• Product Name: 1-BOC-6-CHLOROINDOLE
• Synonyms: 1-BOC-6-CHLOROINDOLE;TERT-BUTYL 6-CHLORO-1H-INDOLE-1-CARBOXYLATE;6-Chloroindole, N-BOC protected;6-Chloroindole, N-BOC protected 98%;BOC-6-CHLOROINDOLE;1-Boc-6-chloro-1H-indole;tert-butyl 6-chloro-1H-indole-3-carboxylate;6-Chloroindole-1-carboxylic acid tert-butyl ester
• CAS NO: 323580-68-3
• Molecular Formula: C₁₃H₁₄ClNO₂
• Molecular Weight: 251.70876
• Product Categories: blocks;IndolesOxindoles;Indole
• Mol File: 323580-68-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 85-87
• Boiling Point: 349.9 °C at 760 mmHg
• Flash Point: 165.4 °C
• Appearance: /
• Density: 1.19
• Vapor Pressure: 4.55E-05mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 1-BOC-6-CHLOROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-6-CHLOROINDOLE(323580-68-3)
• EPA Substance Registry System: 1-BOC-6-CHLOROINDOLE(323580-68-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 323580-68-3(Hazardous Substances Data)

Usage

General Description

1-BOC-6-CHLOROINDOLE is a chemical compound known for its potential applications in the pharmaceutical industry. It is a derivative of the indole family, which is a common structure found in many biologically active compounds. The "1-BOC" in its name refers to the presence of a tert-butoxycarbonyl (BOC) protecting group at the 1 position of the indole ring, which is often used in organic synthesis to protect reactive functional groups. The "6-CHLORO" designation indicates the presence of a chlorine atom at the 6 position of the indole ring, a modification that can impact the compound's reactivity and biological properties. Research into 1-BOC-6-CHLOROINDOLE and its derivatives is ongoing, with potential applications including the development of new drugs and pharmaceutical compounds.

InChI:InChI=1/C13H14ClNO2/c1-13(2,3)17-12(16)15-7-6-9-4-5-10(14)8-11(9)15/h4-8H,1-3H3

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 17422-33-2 6-chloroindole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 352359-22-9 {1-[(tert-butoxy)carbonyl]-6-chloro-1H-indol-2-yl}boronic acid 

Relevant articles and documents

Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof

The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.

A kind of aldosterone synthase modulators method for the preparation of intermediates

The invention discloses a method for preparing an aldosterone synthase conditioning agent intermediate. The method comprises the following steps: implementing reaction on a reaction substrate under Boc protection with hydrogen chloride and ethanol for acetal protection, directly heating to remove Boc protection without separation, implementing N-methylation reaction so as to obtain an N-methylation product, and directly removing acetal protection without separation, thereby obtaining a target product. The method is high in route reaction conversion rate and high in product purity, the product quality can be effectively ensured, and workshop production can be achieved.

Stereoselective palladium-catalyzed carboaminoxylations of indoles with arylboronic acids and TEMPO

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