3242-56-6Relevant articles and documents
PREPARATION OF DIAZO AND DIAZONIUM COMPOUNDS
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Page/Page column 32, (2010/06/13)
A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.
Diazo transfer reaction in solid state
Ghosh,Datta
, p. 191 - 200 (2007/10/02)
A highly efficient methodology in solid state has been developed for the synthesis of α-diazocarbonyl/sulfonyl compounds from active methylene precursors using tosyl azide or 4-carboxybenzenesulfonyl azide and potassium carbonate, devoid of any aqueous work-up, save a column filtration over silica gel.
A Simple Procedure for Preparation of α-Diazocarbonyl Compounds
Rao, Y. Koteswar,Nagarajan, M.
, p. 735 - 737 (2007/10/02)
The use of 1,8-diazabicycloundec-7-ene as a base in Regitz reaction leads to improved yields of α-diazocarbonyl compounds in much shorter time (15 min).
