32433-61-7

Basic information

• Product Name: 2-Bromo-N-(2,6-dimethylphenyl)acetamide
• Synonyms: 2-Bromo-2',6'-dimethylacetanilide;N-Bromoacetyl-2,6-dimethylaniline;2-Bromo-N-(2,6-dimethylphenyl)acetamide
• CAS NO: 32433-61-7
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.11
• Mol File: 32433-61-7.mol
• Article Data: 20

Chemical Properties

• Melting Point: 150-151 ºC
• Boiling Point: 329.8°C at 760 mmHg
• Flash Point: 153.3°C
• Appearance: /
• Density: 1.439
• Vapor Pressure: 0.000173mmHg at 25°C
• Refractive Index: 1.604
• PKA: 12.54±0.70(Predicted)
• CAS DataBase Reference: 2-Bromo-N-(2,6-dimethylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-(2,6-dimethylphenyl)acetamide(32433-61-7)
• EPA Substance Registry System: 2-Bromo-N-(2,6-dimethylphenyl)acetamide(32433-61-7)

Safety Data

• Hazardous Substances Data: 32433-61-7(Hazardous Substances Data)

Usage

General Description

2-Bromo-N-(2,6-dimethylphenyl)acetamide is a chemical compound with the molecular formula C10H12BrNO and a molar mass of 261.11 g/mol. It is a white to off-white powder that is insoluble in water but soluble in organic solvents. 2-Bromo-N-(2,6-dimethylphenyl)acetamide is used in organic synthesis and pharmaceutical research as an intermediate in the production of various pharmaceuticals and agrochemicals. It is also utilized as a reagent in the preparation of various other organic compounds. Additionally, it has been investigated for its potential as an antibacterial and antifungal agent. Overall, 2-Bromo-N-(2,6-dimethylphenyl)acetamide is an important chemical compound with a wide range of applications in the field of chemistry and pharmaceuticals.

InChI:InChI=1/C10H12BrNO/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6H2,1-2H3,(H,12,13)

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 87-62-7 2,6-dimethylaniline 
• 22118-09-8 2-bromoacetyl chloride 
• 79-08-3 bromoacetic acid 

Downstream Products

• 53984-98-8 2-cyano-N-(2,6-dimethyl-phenyl)-acetamide 
• 212261-88-6 1-(2,6-dimethylphenyl)-2,8,8-trioxo-1,4-diaza-7,8-dithianonane 

Relevant articles and documents

Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques

A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized using1 H NMR,13 C NMR, IR, and EI-MS spectroscopic analysis. The intermediate triazole was synthesized through a sequential synthesis of carboxylate and carbohydrazide. The bovine serum albumin (BSA) binding of the newly synthesized 1,2,4-triazole derivatives was evaluated along with thermodynamics, site-selective binding, and synchronous study. The results obtained by BSA binding as well as thermodynamic studies justify that all the compounds show spontaneous interaction with BSA and could be effectively distributed and eliminated from the body. Therefore, the triazole-based analogs might be a useful strategy for designing new drug systems.

PHOSPHONIUM ION CHANNEL BLOCKERS AND METHODS FOR USE

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

A novel method for the synthesis of 1,2,4-triazole-derived heterocyclic compounds: enzyme inhibition and molecular docking studies

Two series of new N-aryl/aralkyl derivatives (9a–q) of 2-(4-ethyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio)acetamide and N-aryl/aralkyl derivatives (10a–q) of 2-(4-phenyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio)acetamide were synthesized. The methods included successive conversions of thiophen-2-acetic acid (a) into its respective ester, hydrazide and N-aryl/aralkyl 1,3,4-triazole. The target compounds (9a–q; 10a–q) were obtained by the reaction of N-aryl/aralkyl 1,3,4-triazole (5, 6) with various electrophiles, (8a–q), in N,N-dimethyl formamide (DMF) and sodium hydroxide at room temperature. The characterization of these compounds was done by FTIR, 1H-, 13C-NMR, EI-MS and HR-EI-MS spectral data. All compounds were evaluated for their enzyme inhibitory potentials against electric eel acetylcholinesterase, AChE (10f, 10d; IC50 values 32.26 ± 0.12, 45.72 ± 0.11?μM, respectively), equine butyrylcholinesterase, BChE (9d, 9l, 9b, 10d, 10h; IC50 values 12.52 ± 0.19, 12.52 ± 0.19, 21.72 ± 0.18, 23.62 ± 0.22, 24.52 ± 0.21?μM, respectively), jack bean urease (10i, 10n, 9e; IC50 values 7.27 ± 0.05, 7.35 ± 0.04, 8.79 ± 0.05?μM, respectively) and yeast α-glucosidase enzymes (9o, 10i; IC50 values 62.94 ± 0.19, and 69.46 ± 0.15?μM, respectively). The molecular docking studies supported these findings. This study provides cheaper bioactive triazole amides as promising future lead molecules.