32511-63-0

Basic information

• Product Name: 1,25-DIHYDROXYVITAMIN D3
• Synonyms: 1,25-DIHYDROXYVITAMIN D3;(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3β,25-triol
• CAS NO: 32511-63-0
• Molecular Formula: C₂₇H₄₄O₃
• Molecular Weight: 416.64
• Mol File: 32511-63-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 565°Cat760mmHg
• Flash Point: 238.4°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 4.05E-15mmHg at 25°C
• Refractive Index: 1.547
• PKA: 14.43±0.40(Predicted)
• CAS DataBase Reference: 1,25-DIHYDROXYVITAMIN D3(CAS DataBase Reference)
• NIST Chemistry Reference: 1,25-DIHYDROXYVITAMIN D3(32511-63-0)
• EPA Substance Registry System: 1,25-DIHYDROXYVITAMIN D3(32511-63-0)

Safety Data

• Hazardous Substances Data: 32511-63-0(Hazardous Substances Data)

Usage

General Description

1,25-dihydroxyvitamin D3, also known as calcitriol, is a naturally occurring hormone in the body that plays a crucial role in regulating calcium and phosphorus levels. It is the active form of vitamin D and is produced in the kidneys from its precursor, 25-hydroxyvitamin D3. 1,25-dihydroxyvitamin D3 acts as a steroid hormone, binding to vitamin D receptors in target tissues such as the intestines, bones, and kidneys, where it promotes the absorption of calcium and phosphorus, enhances bone mineralization, and regulates parathyroid hormone secretion. This hormone also has immunomodulatory and anti-inflammatory effects, playing a role in the regulation of the immune system. Additionally, 1,25-dihydroxyvitamin D3 has been studied for its potential in various health conditions, including osteoporosis, kidney disease, and cancer.

InChI:InChI=1/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25?,27-/m1/s1

Upstream product

• 132054-64-9 (1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-2-methylene-cyclohexanol 
• 19356-17-3 (S)-3-[2-[(1R,3aS)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-methylene-cyclohexanol 
• 19356-17-3 25-hydroxycholecalciferol 
• 140710-90-3 (R)-6-{(1R,3aS)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2-methyl-heptan-2-ol 
• 73809-11-7 (S)-3-[(R)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-ol 
• 132054-64-9 (1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methylene-cyclohexanol 
• 67-97-0 vitamin D₃ 

Relevant articles and documents

Investigation of Vitamin D2 and Vitamin D3 Hydroxylation by Kutzneria albida

The active vitamin D metabolites 25-OH?D and 1α,25-(OH)2?D play an essential role in controlling several cellular processes in the human body and are potentially effective in the treatment of several diseases, such as autoimmune diseases, cardiovascular diseases and cancer. The microbial synthesis of vitamin D2 (VD2) and vitamin D3 (VD3) metabolites has emerged as a suitable alternative to established complex chemical syntheses. In this study, a novel strain, Kutzneria albida, with the ability to form 25-OH?D2 and 25-OH?D3 was identified. To further improve the conversion of the poorly soluble substrates, several solubilizers were tested. 100-fold higher product concentrations of 25-OH?D3 and tenfold higher concentrations of 25-OH?D2 after addition of 5 % (w/v) 2-hydroxypropyl β-cyclodextrin (2-HPβCD) were reached. Besides the single-hydroxylation products, the human double-hydroxylation products 1,25-(OH)2?D2 and 1,25-(OH)2?D3 and various other potential single- and double-hydroxylation products were detected. Thus, K. albida represents a promising strain for the biotechnological production of VD2 and VD3 metabolites.

Direct C-1 hydroxylation of vitamin D compounds: Convenient preparation of 1α-hydroxyvitamin D3, 1α,25-dihydroxyvitamin D3, and 1α-hydroxyvitamin D2

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