325460-75-1

Basic information

• Product Name: (6R)-1-aza-6-hydroxymethyl-4-phenyl-2-oxobicyclo[4.3.0]nonane
• Synonyms: (6R)-1-aza-6-hydroxymethyl-4-phenyl-2-oxobicyclo[4.3.0]nonane
• CAS NO: 325460-75-1
• Molecular Weight: 245.321
• Mol File: 325460-75-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6R)-1-aza-6-hydroxymethyl-4-phenyl-2-oxobicyclo[4.3.0]nonane(CAS DataBase Reference)
• NIST Chemistry Reference: (6R)-1-aza-6-hydroxymethyl-4-phenyl-2-oxobicyclo[4.3.0]nonane(325460-75-1)
• EPA Substance Registry System: (6R)-1-aza-6-hydroxymethyl-4-phenyl-2-oxobicyclo[4.3.0]nonane(325460-75-1)

Safety Data

• Hazardous Substances Data: 325460-75-1(Hazardous Substances Data)

Upstream product

• 325460-61-5 (6R)-1-aza-6-carbomethoxy-4-phenyl-2-oxobicyclo[4.3.0]nonane 
• 157662-40-3 (R)-N-(benzoyloxycarbonyl)-allylproline methyl ester 
• 157662-41-4 (R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester 
• 325460-74-0 (2R)-2-[2'-(phenyl)-3'-(carbomethoxy)-propyl]proline methyl ester 
• 325460-62-6 (2R)-N-(benzyloxycarbonyl)-2-[(E)-3'-(carbomethoxy)prop-2'-enyl]proline methyl ester 
• 325460-63-7 (2R)-N-(benzyloxycarbonyl)-2-[2'-(phenyl)-3'-(carbomethoxy)-propyl]proline methyl ester 

Downstream Products

• 325460-67-1 (6R)-1-aza-6-[(tert-butyldimethylsiloxy)methyl]-3-hydroxy-4-phenyl-2-oxobicyclo[4.3.0]non-3-ene 
• 325460-68-2 (6R)-1-aza-3-amino-6-[(tert-butyldimethylsiloxy)methyl]-4-phenyl-2-oxobicyclo[4.3.0]non-3-ene 
• 325460-77-3 (6R,12S)-1-aza-3-(pyroglutamylamino)-6-formyl-4-phenyl-2-oxobicyclo[4.3.0]non-3-ene 
• 325460-69-3 (6R,12S)-1-aza-3-(pyroglutamylamino)-6-hydroxymethyl-4-phenyl-2-oxobicyclo[4.3.0]non-3-ene 
• 325460-70-6 (6R,12S)-1-aza-3-(pyroglutamylamino)-6-carbomethoxy-4-phenyl-2-oxobicyclo[4.3.0]non-3-ene 
• 325460-76-2 (6R,12S)-1-aza-3-(pyroglutamylamino)-6-[(tert-butyldimethylsiloxy)methyl]-4-phenyl-2-oxobicyclo[4.3.0]non-3-ene 

Relevant articles and documents

Constrained peptidomimetics for TRH: cis-peptide bond analogs

Two constrained analogs of the tripeptide hormone thyroliberin (TRH) have been synthesized. In both, the HisPro peptide bond of the hormone has been 'locked' into a cis-conformation. In the first analog, the constraint used was identical to the constraint used in an earlier trans-peptide bond analog that was a potent agonist for the TRH endocrine receptor TRH-R1. The second analog was built in order to take advantage of a tetrazole ring as the cis-peptide bond constraint. Neither analog showed agonist or antagonist behavior toward TRH-R1 suggesting that the cis-peptide bond conformation may not play a role in the affinity of TRH for TRH-R1. (C) 2000 Elsevier Science Ltd.