325850-81-5 Usage
Description
2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid, also known as GRI-977143, is a non-lipid agonist of the G protein-coupled lysophosphatidic acid receptor 2 (LPA2). It selectively targets LPA2 with an EC50 value of 3.3 μM in LPA2-transfected RH7777 cells and has no activity at LPA1, LPA3, LPA4, and LPA5 at concentrations up to 10 μM. 2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid has potential applications in various fields due to its ability to modulate cell growth, reduce apoptosis, and rescue cells from injury.
Uses
Used in Pharmaceutical Industry:
2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid is used as a therapeutic agent for promoting cell growth and reducing apoptosis in LPA2-transduced MEF fibroblasts. It has potential applications in the treatment of diseases involving cell growth and apoptosis regulation.
Used in Disease Prediction and Management:
2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid is used as a non-lipid agonist of LPA2 for the prediction and management of diseases involving fatty acids, such as coronary heart disease or atherosclerosis. LPA (Lipoprotein Associated Phospholipase A2/A3) are important factors in the prediction of these diseases.
Used in Cancer Research and Treatment:
2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid is used as a compound to increase MM1 rat hepatoma cell invasion and inhibit apoptosis of IEC-6 cells induced by TNF-α, doxorubicin, or serum withdrawal. It also has potential applications in rescuing apoptotic cells from γ-irradiation-induced injury in vitro and in vivo, making it a valuable tool in cancer research and treatment.
Used in Drug Development:
2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid is used as a lead compound in the development of new drugs targeting LPA2 receptors. Its selective agonist activity and potential therapeutic effects make it a promising candidate for further research and development in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 325850-81-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,5,8,5 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 325850-81:
(8*3)+(7*2)+(6*5)+(5*8)+(4*5)+(3*0)+(2*8)+(1*1)=145
145 % 10 = 5
So 325850-81-5 is a valid CAS Registry Number.
