326855-11-2

Basic information

• Product Name: 2-amino-4,6-dimethoxy-5-nitrosopyrimidine
• Synonyms: 2-amino-4,6-dimethoxy-5-nitrosopyrimidine
• CAS NO: 326855-11-2
• Molecular Formula: C₆H₈N₄O₃
• Molecular Weight: 184
• Mol File: 326855-11-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 190-192 °C (decomp)
• Boiling Point: 464.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: 0?+-.0.10(Predicted)
• CAS DataBase Reference: 2-amino-4,6-dimethoxy-5-nitrosopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4,6-dimethoxy-5-nitrosopyrimidine(326855-11-2)
• EPA Substance Registry System: 2-amino-4,6-dimethoxy-5-nitrosopyrimidine(326855-11-2)

Safety Data

• Hazardous Substances Data: 326855-11-2(Hazardous Substances Data)

Upstream product

• 36315-01-2 4,6-dimethoxy-2-aminopyrimidine 

Downstream Products

• 1242052-88-5 N-(2-amino-1,6-dihydro-5-nitroso-6-oxopyrimidin-4-yl)-L-phenylalanine 
• 1242052-86-3 N-(2-amino-6-methoxy-5-nitroso-pyrimidin-4-yl) L-ethyl phenylalaninate 
• 1242052-76-1 2-amino-4-cyclohexylamino-6-methoxy-5-nitrosopyrimidine 
• 1242052-93-2 2-amino-bis(cyclohexylamino)-5-nitrosopyrimidine 
• 1242052-81-8 2-amino-4-(4-carboxyphenylamino)-6-methoxy-5-nitrosopyrimidine 
• 1096144-75-0 2,4-diamino-6-methoxy-5-nitroso-N⁴-phenylpyrimidine 
• 1242052-82-9 2-amino-4-(3-chlorophenylamino)-6-methoxy-5-nitrosopyrimidine 
• 1242052-80-7 2-amino-4-benzylamino-6-methoxy-5-nitrosopyrimidine 
• 1403677-10-0 2-amino-4,6-bis-cyclohexylmethoxy-5-nitrosopyrimidine 
• 1242053-03-7 2-amino-6-aniliino-4-butylamino-5-nitrosopyrimidine 
• 1242053-04-8 C₁₅H₁₈N₆O₃ 
• 1242053-05-9 2-amino-4-(3-chlorophenylamino)-6-isopropyl-5-nitrosopyrimidine 
• 1242053-01-5 2-amino-4-benzylamino-6-isopropylamino-5-nitrosopyrimidine 
• 1242053-00-4 2-amino-4-benzylamino-6-methylamino-5-nitrosopyrimidine 

Relevant articles and documents

Novel procedure for selective C-nitrosation of aminopyrimidine derivatives under neutral conditions. Scope and synthetic applications

A novel simple method, based on treatment with isoamyl nitrite (IAN) in DMSO without any added acid, to produce selective C(5)-nitrosation of aminopyrimidine derivatives is described. It proved to be suitable for a multigram scale and applicable to a larger range of pyrimidine derivatives, including amino-dialkoxypyrimidines, than the procedures previously known. Its scope is analyzed and some example on the usefulness of the newly prepared substances as intermediates in the synthesis of fused heterobicyclic derivatives of potential biological interest is presented.

HAIR COLOURANTS COMPRISING TETRAAMINOPYRIMIDINE DERIVATES

The present disclosure relates to compositions for colouring keratin fibres, in particular human hair, where the composition comprises, in a cosmetic carrier, at least one neutral tetraaminopyrimidine derivate of the general formula (I), (I) in which R1, R2 independently of one another are a group of the formulae (II), (III) or (IV) —(CH2)n— (II) —(CH2)m—O—(CH2)p— (III) —(CH2)m—N(R3)-(CH2)p— (IV) n is 2, 3, 4, 5 or 6, m, p in each case independently of one another are 1, 2 or 3, Y is —OH, —NH2 or —NH-alkyl, R3 is a hydrogen atom, a C1-C6-alkyl group or is a C2-C6-alkenyl group.

Alkoxy-5-nitrosopyrimidines: Useful building block for the generation of biologically active compounds

Several alkoxy-5-nitrosopyrimidines were synthesised and high regioselective and sequential nucleophilic aromatic substitution of methoxy groups in 2-am:ino-4,6-d.imetho;xy-5nitrosopyrimidine was observed. The approach was applied to the synthesis of valu