326897-98-7Relevant articles and documents
Asymmetric synthesis of photophore-containing lactisole derivatives to elucidate sweet taste receptors
Hashimoto, Makoto,Ishida, Akiko,Misaka, Takumi,Nakagita, Tomoya,Tachrim, Zetryana Puteri,Wang, Lei
, (2020/06/30)
Lactisole, which has a 2-phenoxy propionic acid skeleton, is well-known as an inhibitor of sweet taste receptors. We recently revealed some of the structure-activity relationships of the aromatic ring and chiral center of lactisole. Photoaffinity labeling
Structure-Activity Relations. Part 11. Biologically Active 2-Phenoxy-N-phenyl-3-pyridinecarboxamides: Potential Photoaffilnity Labels and Fused-ring Analogues
Bowden, Keith,Malik, Faisal P.,Pallett, Ken E.,Tomlinson, Ian D.
, p. 2901 - 2919 (2007/10/02)
Four substituted 2-phenoxy-N-phenyl-3-pyridinecarboxamides having azido or trifluoromethyldiazirinyl substituents have been prepared as potential photoaffinity labels for phytoene desaturase.Intramolecular hydrogen-bonding has been found to occur in 2-phenoxy-N-phenyl-3-pyridinecarboxamides.This finding and molecular graphic studies led to the design and synthesis of some substituted 1,3-diphenylpyridopyrimidine-2(1H),-4(3H)-diones and 1,3-diphenyl-2,3-dihydropyridopyrimidin-4(1H)-ones and a 4-hydroxy-1,3-diphenyl-1,8-naphthyridin-2(1H)-one.The biological activities of selected compounds towards Daucus carota have been measured.