327-46-8

Basic information

• Product Name: ethyl 2-fluorobutanoate
• CAS NO: 327-46-8
• Molecular Formula: C₆H₁₁FO₂
• Molecular Weight: 134.1487
• Mol File: 327-46-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 141.9°C at 760 mmHg
• Flash Point: 39.3°C
• Density: 0.98g/cm³
• Vapor Pressure: 5.73mmHg at 25°C
• Refractive Index: 1.38
• CAS DataBase Reference: ethyl 2-fluorobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-fluorobutanoate(327-46-8)
• EPA Substance Registry System: ethyl 2-fluorobutanoate(327-46-8)

Safety Data

• Hazardous Substances Data: 327-46-8(Hazardous Substances Data)

Upstream product

• 65946-52-3 1-Ethoxy-1-trimethylsilyloxy-1-buten 
• 22621-37-0 ethyl 2-aminobutyrate 
• 533-68-6 2-bromobutyric acid ethyl ester 
• 64-17-5 ethanol 
• 2027-81-8 2-Fluor-buttersaeure-chlorid 

Downstream Products

• 833-34-1 2-fluoro-pentanoic acid N-methyl-anilide 
• 29114-74-7 2-Fluoro-1,1-diphenyl-butan-1-ol 
• 23071-44-5 2-fluoro-1-phenyl-1-butanone 

Relevant articles and documents

Fluorination with aminosulfur trifluorides

A fluorination method of oxygen and halogen sites with diaryl-, dialkoxyalkyl-, alkylalkoxyalkyl-, arylalkoxyalkyl- and cyclic aminosulfur trifluorides fluorinating reagents is disclosed.

Alkylation of (Fluorocarbethoxymethylene)-tri-n-butylphosphorane: A Facile Entry to α-Fluoroalkanoates

(Fluorocarbethoxymethyl)trialkylphosphonium bromides 6, prepared from ethyl bromofluoroacetate and tertiary phosphines, react with n-butyllithium in THF to give the corresponding phosphoranes 7.Reaction of the pregenerated (fluorocarbethoxymethylene)tri-n-butylphosphorane 7a with primary alkyl iodides and activated alkyl bromides followed by in situ hydrolysis of the alkylated salts provides the fluoroalkanoates 9 in a one-pot reaction.In the case of secondary alkyl halides, no substitution was observed, the main reaction being decomposition of the phosphorane.However, the anion obtained from diisopropyl (fluorocarbethoxymethyl)phosphonate 10 b reacts with CH3CH(Ph)Br and (CH3)2CHI to afford the corresponding alkylated phosphonates in good yields.Displacement of the phosphonate moiety either by base-induced hydrolysis or by reduction was unsuccessful.