327-52-6

Basic information

• Product Name: 1-Bromo-2,4,5-trifluorobenzene
• Synonyms: 1-BROMO-2,4,5-TRIFLUOROBENZENE;2,4,5-TRIFLUOROBROMOBENZENE;2-BROMO-1,4,5-TRIFLUOROBENZENE;2,4,5-TRIFLUOROBENZOBROMIDE;1-Bromo-2,4,5-trifluorobenzene 99%;1-Bromo-2,4,5-trifluorobenzene99%;1-BROMO-2,4,5-TRIFLUOROBENZENE 98+%;2,4,5-Trifluorophenyl bromide
• CAS NO: 327-52-6
• Molecular Formula: C₆H₂BrF₃
• Molecular Weight: 210.98
• EINECS: 206-318-8
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Miscellaneous;Benzenes;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 327-52-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: −19 °C(lit.)
• Boiling Point: 144 °C(lit.)
• Flash Point: 132 °F
• Appearance: clear slightly yellow liquid
• Density: 1.802 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00557mmHg at 25°C
• Refractive Index: n20/D 1.485(lit.)
• Storage Temp.: 2-8°C
• Solubility: water: insoluble
• Water Solubility: insoluble
• BRN: 1636588
• CAS DataBase Reference: 1-Bromo-2,4,5-trifluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2,4,5-trifluorobenzene(327-52-6)
• EPA Substance Registry System: 1-Bromo-2,4,5-trifluorobenzene(327-52-6)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38-10
• Safety Statements: 26-36/37/39-37/39-16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 327-52-6(Hazardous Substances Data)

Usage

Chemical Properties

clear slightly yellow liquid

Uses

Different sources of media describe the Uses of 327-52-6 differently. You can refer to the following data:
1. 1-Bromo-2,4,5-trifluorobenzene is the intermediate of liquid crystals. The derivatives of this compound can be used as intermediates for the synthesis of qunolone antibacterial. It is employed in the synthesis of 3-ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2, 4, 5-trifluorobenzoic acids from 1-bromo-2, 4, 5-trifluorobenzene and 2, 4, 5-trifluoro-3-hydroxybenzoic acid.
2. Intermediates of Liquid Crystals

General Description

1-Bromo-2,4,5-trifluorobenzene undergoes Br-Mg-exchange reaction with i-PrMgBr in THF to yield organomagnesium compound.

InChI:InChI=1/C8H5F3N2/c9-8(10,11)6-3-5(4-12)1-2-7(6)13/h1-3H,13H2

Upstream product

• 367-23-7 1,2,4-trifluorobenzene 
• 7726-95-6 bromine 
• 363-80-4 2,3,5-trifluoro aniline 
• 62-53-3 aniline 
• 367-25-9 2,4-difluorophenylamine 
• 541-73-1 1,3-Dichlorobenzene 
• 611-06-3 2,4-dichloronitrobenzene 
• 446-35-5 2,4-Difluoronitrobenzene 
• 367-34-0 2,4,5-trifluoroaniline 

Downstream Products

• 147425-22-7 2-(3-Bromo-2,5,6-trifluoro-phenyl)-propan-2-ol 
• 98349-22-5 2,4,5-trifluorobenzonitrile 
• 306307-99-3 P,P'-(1,2-ethanediyl)bis[bis(2,4,5-trifluorophenyl)phosphane] 
• 631899-56-4 (2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(2,4,5-trifluoro-phenyl)-tetrahydro-furan-2-ol 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 
• 98349-24-7 ethyl 2,4,5-trifluorobenzoylacetate 
• 874359-93-0 8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 118829-12-2 3-bromo-2,5,6-trifluorobenzoic acid 
• 137234-99-2 5-bromo-2,3,6-trifluoro benzaldehyde 
• 680993-47-9 1-allyl-2,4,5-trifluorobenzene 
• 1242069-63-1 (R)-benzyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 881995-73-9 3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 1-BROMO-2,4,5-TRIFLUOROBENZENE

The present invention relates to a process for the preparation of l-bromo-2,4,5-trifluorobenzene from 2,4,5-trifhioroaniline or sulfate salt thereof. The present invention also relates to a process for the preparation of 1,2,4-trifluorobenzene from 2,4,5-trifluoroaniline and then converting into 1-bromo-2,4,5 -trifluorobenzene.

Efficient preparation method of 2, 4, 5-trifluorophenylacetic acid

The invention discloses an efficient preparation method of 2, 4, 5-trifluorophenylacetic acid and belongs to the technical field of synthesis of a pharmaceutical intermediate. The preparation method comprises synthesis of 2, 3, 5-trifluoroaniline, synthesis of 1, 2, 4-trifluorobenzene, synthesis of trifluorobromobenzene and synthesis of a desired product 2, 4, 5-trifluorophenylacetic acid. The preparation method is simple and easy to operate, utilizes cheap and easily available raw materials and has high reaction efficiency and good repeatability.

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.