32771-73-6Relevant articles and documents
Synthesis of N-terminal substituted anthranilic acid dimer derivatives for evaluation on CCK receptors
Varnavas, Antonio,Valenta, Valentina,Berti, Federico,Lassiani, Lucia
, p. 555 - 564 (2001)
A series of new N-substituted anthranilic acid dimer derivatives having a C-terminal Phe residue was synthesized and evaluated for their affinity for CCK receptors. These compounds resulted from a blended approach based firstly on the use of an alternative substructure embedded within asperlicin and secondly on the derivatization of this template with substituents chosen considering the C-terminal primary structure of the endogenous ligand. Although these compounds exhibited a regnylogical-type organization similar to that of CCK-4, they are characterized by about 1000-fold greater affinity for CCK-A receptor than the C-terminal tetrapeptide.
ANTHRANYL DERIVATIVES HAVING AN ANTICHOLECYSTOKININ ACTIVITY (ANTI-CCK-1), A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL USE THEREOF
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Page 7-8, (2008/06/13)
Anthranylic compounds having anti-CCK activity of general formula (I) in which, n is a whole number lying between 0 and 7; R1 is chosen independently from the groups (II), in which X1 is chosen independently from, S, O, NR2/sub
C-terminal anthranoyl-anthranilic acid derivatives and their evaluation on CCK receptors
Varnavas, Antonio,Lassiani, Lucia,Luxich, Elena,Valenta, Valentina
, p. 293 - 302 (2007/10/03)
A series of C-terminal anthranoyl-anthranilic acid derivatives arising from a strict bond disconnection approach of asperlicin were synthesized and examined for their CCK receptor affinities. These compounds represent the second step of our investigation