328056-86-6Relevant articles and documents
The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL im from: Thermomyces lanuginosus in a continuous flow microreactor
Du, Li-Hua,Dong, Zhen,Long, Rui-Jie,Chen, Ping-Feng,Xue, Miao,Luo, Xi-Ping
, p. 807 - 812 (2019)
A fast and green protocol for the Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor was developed. In contrast with existing methods, this method is simple (35 min), uses mild reaction conditions (45 °C) and is environmentally friendly. This enzymatic Michael addition performed in continuous flow microreactors is an innovation that may open up the use of enzymatic microreactors in imidazole analogue biotransformations.
Method for catalytically synthesizing N, N'-disubstituted urea derivative and imidazole derivative
-
Paragraph 0065; 0066; 0067; 0068, (2016/10/17)
The present invention relates to a green and efficient method for preparing an N, N'-disubstituted urea derivative and an imidazole derivative. The method for preparing the N, N'-disubstituted urea derivative by condensation of an aromatic amine with a carbonate ester comprises: by using ionic liquid loaded magnetic nanoparticles as a catalyst, at the temperature of 60-100 DEG C, and at a normal pressure, and in a condition of solvent-free, performing a condensing reaction on the aromatic amine and the carbonate ester for 8-14 hours to obtaina corresponding N, N'-disubstituted urea derivative; by using a magnetic nanoparticle-loaded ionic liquid as a catalyst and by using ethanol as a solvent, performing Michael addition reaction of a substituted imidazole and an electron-deficient olefin for 1-5 hours at the temperature of 10-50 DEG C and at a normal pressure to obtain a corresponding imidazole derivative, wherein the catalyst is as shown in the specification. Experiments verify that after the reaction is completed, the catalyst is recycled simply through an external magnetic field and can be repeatedly used for many times, but the activity is not obviously reduced. The catalytic system is simple in operation and high in yield, and the reusability is good, so that the method has a good industrial prospect.
Michael-type addition of azoles of broad-scale acidity to methyl acrylate
Boncel, Slawomir,Saletra, Kinga,Hefczyc, Barbara,Walczak, Krzysztof Z.
supporting information; experimental part, p. 173 - 178 (2011/05/19)
An optimisation of Michael-type addition of azole derivatives of broad-scale acidity - ranging from 5.20 to 15.00 pKa units - namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5)-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-
