328081-53-4

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[3-(trifluoromethyl)phenoxy]-
• CAS NO: 328081-53-4
• Molecular Formula: C15H8F3NO3
• Molecular Weight: 307.229
• Mol File: 328081-53-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[3-(trifluoromethyl)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[3-(trifluoromethyl)phenoxy]-(328081-53-4)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[3-(trifluoromethyl)phenoxy]-(328081-53-4)

Safety Data

• Hazardous Substances Data: 328081-53-4(Hazardous Substances Data)

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 

Downstream Products

• 1443440-58-1 C₉H₈F₃NO₂ 
• 99907-98-9 O-(3-(trifluoromethyl)phenyl)hydroxylamine 

Relevant articles and documents

Rh(iii)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using α-diazomalonates

Here we report a new and mild Rh(iii)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using α-diazomalonates. This reaction provided a straightforward way for installing both an α-quaternary carbon center and a free-OH moiety into the phenyl ring, thus giving access to useful 2-(2-hydroxyphenyl)-2-alkoxymalonates with good substrate/functional group tolerance. This journal is

Rhodium(III)-catalysed cascade [3 + 2] annulation of: N -aryloxyacetamides with 3-(hetero)arylpropiolic acids: Synthesis of benzofuran-2(3 H)-ones

Herein, a cascade [3 + 2] annulation of N-aryloxyacetamides with 3-(hetero)arylpropiolic acids affording benzofuran-2(3H)-ones via rhodium(iii)-catalyzed redox-neutral C-H functionalization/isomerization/lactonization using an internal oxidative directing group O-NHAc was achieved. This catalytic system provides a regio- and stereoselective approach to synthesize (Z)-3-(amino(aryl)methylene)benzofuran-2(3H)-ones with exclusive Z configuration selectivity, acceptable yields and good functional group tolerance. Preliminary investigations on ultraviolet-visible and fluorescence behaviors reveal that the annulation products may be applied as a promising fluorescent probe for sensing metal cations, especially for cerium (Ce3+).

Rhodium(III)-catalyzed C-H olefination for the Synthesis of ortho-alkenyl phenols using an oxidizing directing group

By using an oxidizing directing group, a mild, efficient Rh(III) catalyzed C-H olefination reaction between N-phenoxyacetamides and alkenes was developed. This reaction provided a straightforward way for the synthesis of ortho-alkenyl phenols, and the directing group is traceless in the product.