328541-79-3

Basic information

• Product Name: (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
• Synonyms: (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE;GLYH-101;CFTR Inhibitor II;Glycine, N-2-naphthalenyl-, [(3,5-dibroMo-2,4-dihydroxyphenyl)Methylene]hydrazide;N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;GlyH 101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide CFTR Inhibitor II
• CAS NO: 328541-79-3
• Molecular Formula: C19H15Br2N3O3
• Molecular Weight: 493.15
• Product Categories: CFTR Inhibitor II, GlyH-101 is a cell-permeable glycinyl hydrazone compound.;Inhibitors
• Mol File: 328541-79-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: >300℃ (ethanol )
• Appearance: /
• Density: 1.73±0.1 g/cm3(Predicted)
• Storage Temp.: = -70C
• PKA: 5.44±0.45(Predicted)
• CAS DataBase Reference: (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE(328541-79-3)
• EPA Substance Registry System: (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE(328541-79-3)

Safety Data

• Hazardous Substances Data: 328541-79-3(Hazardous Substances Data)

Usage

Description

(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE, also known as GlyH-101, is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective, and reversible open-channel blocker of the CFTR (Cystic Fibrosis Transmembrane conductance Regulator) channel. It selectively and reversibly blocks the CFTR channel, binding to a site at the external pore of CFTR and rapidly preventing chloride transport. GlyH-101 has shown minimal effects on P-glycoprotein and non-CFTR-mediated Clcurrents and has been effective in nasal and intestinal epithelia in vivo.

Uses

Used in Pharmaceutical Applications:
(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE is used as a CFTR channel blocker for the treatment of cystic fibrosis and related chloride transport disorders. It modulates the CFTR channel, reducing chloride transport and potentially alleviating symptoms associated with these conditions.
Used in Research Applications:
In the field of research, (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE is used as a tool to study the function and regulation of CFTR channels. It helps researchers understand the role of these channels in various physiological processes and the development of potential therapeutic strategies for related diseases.
Used in Drug Development:
(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE serves as a lead compound in the development of new drugs targeting CFTR channels. Its potent and selective blocking activity makes it a valuable starting point for designing more effective and specific therapeutic agents for cystic fibrosis and other related conditions.
Used in Cardiology:
(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE is used as a blocker of cardiac I Cl.PKA channels, which may have potential applications in the treatment of certain cardiac conditions. Studies have shown that GlyH-101 blocks these channels in a similar fashion to that reported for recombinant CFTR, suggesting its potential use in modulating cardiac ion channel activity.

Biochem/physiol Actions

Cell permeable: yes