32858-93-8

Basic information

• Product Name: 2-Trifluoromethoxyphenol
• Synonyms: 2-HYDROXYPHENYL TRIFLUOROMETHYL ETHER;2-(TRIFLUOROMETHOXY)PHENOL;O-TRIFLUOROMETHOXY PHENOL;2-hydroxytrifluoromethoxybenzene;o-Trifluoromethoxy Phenol 2-Trifluoromethoxy Phenol;m-Hydroxytrifluoromethoxybenzene;TRIFLUORMETHOXYPHENOL;2-(Trifluoromethoxy)phenol 98%
• CAS NO: 32858-93-8
• Molecular Formula: C₇H₅F₃O₂
• Molecular Weight: 178.11
• EINECS: -0
• Product Categories: Trifluoroanisole series;Aromatic Phenols;Phenol&Thiophenol&Mercaptan
• Mol File: 32858-93-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 69-71°C 60mm
• Flash Point: 47°C
• Appearance: colorless transparent liquid
• Density: 1,332 g/cm3
• Refractive Index: 1.443
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.22±0.30(Predicted)
• BRN: 1869013
• CAS DataBase Reference: 2-Trifluoromethoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Trifluoromethoxyphenol(32858-93-8)
• EPA Substance Registry System: 2-Trifluoromethoxyphenol(32858-93-8)

Safety Data

• Hazard Codes: Xi,T
• Statements: 10-20/21/22-34-43-36-25-36/38
• Safety Statements: 26-36/37/39-45-36/37
• RIDADR: 2927
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 32858-93-8(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

Upstream product

• 456-55-3 1-trifluoromethoxybenzene 
• 261952-22-1 1-methoxy-2-(trifluoromethoxy)benzene 

Downstream Products

• 690264-39-2 4-bromo-2-(trifluoromethoxy)phenol 
• 1027269-90-4 4,6-dibromo-2-trifluoromethoxyphenol 
• 352314-76-2 1-(prop-2-ynyloxy)-2-(trifluoromethoxy)benzene 
• 497959-31-6 2-hydroxy-3-(trifluoromethoxy)benzaldehyde 
• 847872-06-4 2-trifluoromethoxy-4-(phenyldiazenyl)phenol 
• 129644-61-7 1,2-bis-trifluoromethoxybenzene 
• 603-45-2 aurin 
• 1613166-05-4 3-[4-(2-trifluoromethoxyphenoxymethyl)phenyl]isoxazole-5-carboxylic acid amide 
• 1233530-99-8 methyl (2-(trifluoromethoxy)phenyl) carbonate 
• 1224466-89-0 4-[2-trifluoromethoxyphenoxy]pyridine 
• 1167435-64-4 C₂₃H₂₇F₃N₂O₄ 
• 1073488-42-2 8-(2-(trifluoromethoxy)phenoxy)-3-(1-(4-chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3-a]pyrazine 

Relevant articles and documents

Lability of the trifluoromethyl group of trifluoromethoxybenzenes under HF/Lewis acid conditions

The trifluoromethyl functionality of trifluoromethoxybenzenes (trifluoromethyl phenyl ethers) becomes labile under HF/Lewis acid conditions. Substrates with an unsubstituted para-position shed their -CF3 groups while performing a Friedel-Crafts reaction upon another substrate molecule's trifluoromethoxy group to generate p-rosolic acids. Substrates that had blocking groups at the para-positions reacted ortho. The electron donating substituents methoxy and phenoxy interfered with the formation of rosolic acids.