32890-92-9

Basic information

• Product Name: 2,3,4,6-TETRAFLUOROBENZOIC ACID
• Synonyms: 2,3,4,6-TETRAFLUOROBENZOIC ACID;2,3,4,6-Tetrafluorobenzoicacid98%
• CAS NO: 32890-92-9
• Molecular Formula: C₇H₂F₄O₂
• Molecular Weight: 194.08
• Mol File: 32890-92-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 98-99.5 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 223.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.633±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 1.94±0.10(Predicted)
• CAS DataBase Reference: 2,3,4,6-TETRAFLUOROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,6-TETRAFLUOROBENZOIC ACID(32890-92-9)
• EPA Substance Registry System: 2,3,4,6-TETRAFLUOROBENZOIC ACID(32890-92-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 32890-92-9(Hazardous Substances Data)

Usage

Uses

2,?3,?4,?6-?Tetrafluorobenzoic Acid is a reagent used in the preparation of nicotinamide derivatives that act as a new class of gastric (H+?/K+)?-?ATPase inhibitors.

Upstream product

• 1551-39-9 2,4,5,6-tetrafluoroisophthalic acid 
• 124-38-9 carbon dioxide 
• 2367-82-0 1,2,3,5-tetrafluorobenzene 
• 53001-70-0 2,4,5,6-tetrafluorobenzyl alcohol 
• 1559-86-0 2-bromo-1,3,4,5-tetrafluorobenzene 

Downstream Products

• 123016-51-3 2,3,4,6-tetrafluorobenzoyl chloride 
• 119916-22-2 3,4,6-trifluoro-2-methylbenzoic acid 
• 32960-43-3 3-Nitrotetrafluorbenzoesaeure 
• 53001-70-0 2,4,5,6-tetrafluorobenzyl alcohol 
• 1354960-97-6 tert-butyl 2,3,4,6-tetrafluorobenzoate 
• 123016-61-5 3,4,6-trifluoro-2-<(phenylmethyl)amino>benzoic acid 
• 123016-65-9 ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate 
• 123016-66-0 5-(Acetyl-benzyl-amino)-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 123016-64-8 3-[2-(Acetyl-benzyl-amino)-3,4,6-trifluoro-phenyl]-3-oxo-propionic acid ethyl ester 
• 123016-62-6 2--3,4,6-trifluorobenzoic acid 
• 132112-02-8 2-(Acetyl-benzyl-amino)-3,4,6-trifluoro-benzoyl chloride 
• 124487-35-0 1-Cyclopropyl-6,7-difluoro-5-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 124487-34-9 (Z)-3-Cyclopropylamino-2-(3,4,6-trifluoro-2-methoxy-benzoyl)-acrylic acid ethyl ester 
• 124487-33-8 (Z)-3-Ethoxy-2-(3,4,6-trifluoro-2-methoxy-benzoyl)-acrylic acid ethyl ester 

Relevant articles and documents

Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation

Heptapeptide SFLLRNP is a receptor–tethered ligand of protease-activated receptor 1 (PAR-1), and its Phe at position 2 is essential for the aggregation of human platelets. To validate the structural elements of the Phe-phenyl group in receptor activation, we have synthesized a complete set of S/Phe/LLRNP peptides comprising different series of fluorophenylalanine isomers (Fn)Phe, where n = 1, 2, 3, and 5. Phe-2-phenyl was strongly suggested to be involved in the edge-to-face CH/π interaction with the receptor aromatic group. In the present study, to prove this receptor interaction definitively, we synthesized another series of peptide analogs containing (F4)Phe-isomers, with the phenyl group of each isomer possessing only one hydrogen atom at the ortho, meta, or para position. When the peptides were assayed for their platelet aggregation activity, S/(2,3,4,6-F4)Phe/LLRNP and S/(2,3,4,5-F4)Phe/LLRNP exhibited noticeable activity (34% and 6% intensities of the native peptide, respectively), whereas S/(2,3,5,6-F4)Phe/LLRNP was completely inactive. The results indicated that, at the ortho and meta positions but not at the para position, benzene-hydrogen atoms are required for the CH/π interaction to activate the receptor. The results provided a decisive evidence of the molecular recognition property of Phe, the phenyl benzene-hydrogen atom of which participates directly in the interaction with the receptor aromatic π plane.

Halogen Bonding Directed Supramolecular Quadruple and Double Helices from Hydrogen-Bonded Arylamide Foldamers

Halogen bonding has been used to glue together hydrogen-bonded short arylamide foldamers to achieve new supramolecular double and quadruple helices in the solid state. Three compounds, which bear a pyridine at one end and either a CF2I or fluor

CHEMICAL COMPOUNDS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain