328918-85-0

Basic information

• Product Name: 2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethanol
• Synonyms: 2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethanol
• CAS NO: 328918-85-0
• Molecular Weight: 279.338
• Mol File: 328918-85-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethanol(328918-85-0)
• EPA Substance Registry System: 2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethanol(328918-85-0)

Safety Data

• Hazardous Substances Data: 328918-85-0(Hazardous Substances Data)

Upstream product

• 939909-82-7 C₁₈H₁₅NO₃ 
• 1122-91-4 4-bromo-benzaldehyde 
• 328918-82-7 2-(4-bromophenyl)-5-methyl-4-oxazoleacetic acid 
• 328918-83-8 [2-(4-bromophenyl)-5-methyloxazole-4-yl]-acetonitrile 
• 328918-81-6 2-(4-bromophenyl)-4-(chloromethyl)-5-methyl-1,3-oxazole 
• 328918-80-5 4,5-dimethyl-2-(4-bromophenyl)-oxazole oxide 
• 328918-84-9 2-(4-bromophenyl)-5-methyl-4-oxazoleethanol 
• 98-80-6 phenylboronic acid 

Downstream Products

• 401468-49-3 3-{4-[2-(2-Biphenyl-4-yl-5-methyloxazol-4-yl)ethoxy]-phenyl}-2-methyl-2-phenoxypropionic acid 
• 698347-45-4 3-{4-[2-(2-biphenyl-4-yl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-methyl-2-phenoxypropionic acid ethyl ester 
• 853260-27-2 3-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-p-tolyloxy-propionic acid ethyl ester 
• 1189748-84-2 C₂₇H₂₁NO₃S 
• 1065336-00-6 (S)-1-(3-(2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethoxy)benzyl)pyrrolidine-2-carboxylic acid 
• 1173794-76-7 C₃₇H₃₁ClN₂O₅ 
• 1173794-32-5 C₄₃H₃₅ClN₂O₅ 
• 908373-15-9 C₂₉H₂₃NO₆ 
• 1065336-01-7 (S)-1-(3-(2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethoxy)benzyl)pyrrolidine-2-carboxylic acid methyl ester 
• 1065332-12-8 (R)-3-(3-(2-(biphenyl-4-yl)-5-methyloxazol-4-ylethoxy)benzyl)thiazolidine-4-carboxylic acid methyl ester 
• 328918-88-3 2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester 
• 328918-26-9 2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid 
• 478541-69-4 3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester 
• 956091-28-4 C₃₁H₃₁NO₄ 

Relevant articles and documents

Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

Design, synthesis, and SAR of novel α-alkoxy-β-arylpropionic acids as potent and balanced PPARαγ coagonists are described. One representative thereof, Aleglitazar ((S)-2Aa), was chosen for clinical development. Its X-ray structure in complex with both receptors as well as its high efficacy in animal models of T2D and dyslipidemia are also presented.

HETEROCYCLIC COMPOUNDS AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS, USEFUL FOR THE TREATMENT AND/OR PREVENTION OF DISORDERS MODULATED BY A PPAR

The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

Design and synthesis of 2-methyl-2-{4-[2-(5-methyl-2-aryloxazol-4-yl)ethoxy]phenoxy}propionic acids: A new class of dual PPARα/γ agonists

Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARγ- and PPARα-selective compounds, exhibits potent dual PPARα/γ agonist activity as demonstrated by in vitro binding and dose overlap in the newly