329-63-5

Basic information

• Product Name: DL-ADRENALINE HYDROCHLORIDE
• Synonyms: (±)-4-[1-hydroxy-2-(methylamino)ethyl]pyrocatechol hydrochloride;Adrenaline Hcl， racepinephrine hcl;1,2-Benzenediol, 4-1-hydroxy-2-(methylamino)ethyl-, hydrochloride;rs-epinephrine hcl;RACEPINEPHRINEHYDROCHLORIDE,USP;(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride;(±)-Epirenamine hydrochloride;(±)-Epinephrine hydrochloride,(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
• CAS NO: 329-63-5
• Molecular Formula: C₉H₁₃NO₃*ClH
• Molecular Weight: 219.67
• EINECS: 206-346-0
• Product Categories: API
• Mol File: 329-63-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 157°
• Boiling Point: 413.1 °C at 760 mmHg
• Flash Point: 207.9 °C
• Appearance: solid
• Storage Temp.: 2-8°C
• Solubility: H2O: >50 mg/mL
• Stability: Stable, but light sensitive. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.
• Merck: 14,3619
• CAS DataBase Reference: DL-ADRENALINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-ADRENALINE HYDROCHLORIDE(329-63-5)
• EPA Substance Registry System: DL-ADRENALINE HYDROCHLORIDE(329-63-5)

Safety Data

• Hazard Codes: T
• Statements: 24/25-36/37/38
• Safety Statements: 26-36/37-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: DO3330000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 329-63-5(Hazardous Substances Data)

Usage

Chemical Properties

solid

Uses

Different sources of media describe the Uses of 329-63-5 differently. You can refer to the following data:
1. bronchodilatator,
2. An adrenergic receptor agonist.
3. (±)-Epinephrine hydrochloride has been used:in the induction of renalase expression in Human renal proximal tubular epithelial cellsin the infusion studies to test its effect on heart rate and eye temperature measurements in bullas a medium supplement for the stimulation of endothelial progenitor cells

General Description

Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system. It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors. Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.

Biochem/physiol Actions

Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.

InChI:InChI=1/C9H13NO3.2ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;;/h2-4,9-13H,5H2,1H3;2*1H/p-1/t9-;;/m0../s1

Upstream product

• 87697-27-6 tert-butyl [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](methyl)carbamate 

Relevant articles and documents

A new and efficient route for the synthesis of naturally occurring catecholamines

Catecholamines, sympathomimetic drugs and adrenergic receptor antagonists, have been prepared by a regioselective oxidation of the corresponding 4-hydroxyphenethylamine derivatives by 2-iodoxybenzoic acid (IBX) in homogeneous as well as in heterogeneous conditions and followed by cleavage of the amino protective group. By using polymer-supported IBX, after the first oxidation, the oxidant can be recovered, regenerated, and efficiently reused for several additional times. An efficient, easy and green procedure for the synthesis of N-(methoxycarbonyl)dopamine, key component of many pharmaceuticals, has also been reported. Georg Thieme Verlag Stuttgart.