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3296-90-0

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3296-90-0 Usage

Uses

Different sources of media describe the Uses of 3296-90-0 differently. You can refer to the following data:
1. It is a brominated flame retardant, previously shown to be a multisite carcinogen in experimental animals. The compound is used as a fire retardant in unsaturated polyester resins, in molded products, and in rigid polyurethane foam. It shows clear evidence of carcinogenicity and genotoxicity activity.
2. It is a brominated flame retardant, previously shown to be a multisite carcinogen in experimental animals. , and in rigid polyurethane foam. It shows clear evidence of carcinogenicity and genotoxicity

Chemical Properties

Solid

General Description

Off-white powder.

Air & Water Reactions

Hygroscopic . Insoluble in water.

Fire Hazard

Literature sources indicate that 2,2-Bis(bromomethyl)propane-1,3-diol is nonflammable.

Carcinogenicity

The flame retardant 2,2-bis(bromomethyl)-1,3-propanediol, technical grade, is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Check Digit Verification of cas no

The CAS Registry Mumber 3296-90-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,2,9 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3296-90:
(6*3)+(5*2)+(4*9)+(3*6)+(2*9)+(1*0)=100
100 % 10 = 0
So 3296-90-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H10Br2O2/c6-1-5(2-7,3-8)4-9/h8-9H,1-4H2

3296-90-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Aldrich

  • (301930)  2,2-Bis(bromomethyl)-1,3-propanediol  98%

  • 3296-90-0

  • 301930-25G

  • 439.92CNY

  • Detail
  • Aldrich

  • (301930)  2,2-Bis(bromomethyl)-1,3-propanediol  98%

  • 3296-90-0

  • 301930-1KG

  • 1,083.42CNY

  • Detail
  • Aldrich

  • (301930)  2,2-Bis(bromomethyl)-1,3-propanediol  98%

  • 3296-90-0

  • 301930-3KG

  • 2,754.18CNY

  • Detail

3296-90-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-Bis(bromomethyl)propane-1,3-diol

1.2 Other means of identification

Product number -
Other names FR 1138

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Flame retardants
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3296-90-0 SDS

3296-90-0Synthetic route

Pentaerythritol
115-77-5

Pentaerythritol

acetic acid
64-19-7

acetic acid

A

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

B

2,2-bis(bromomethyl)-3-bromo-propan-1-ol
1522-92-5

2,2-bis(bromomethyl)-3-bromo-propan-1-ol

C

3-bromo-2,2-bis(bromomethyl)propyl acetate
3580-97-0

3-bromo-2,2-bis(bromomethyl)propyl acetate

D

3-bromo-2-(bromomethyl)-2-(hydroxymethyl)propylacetate

3-bromo-2-(bromomethyl)-2-(hydroxymethyl)propylacetate

Conditions
ConditionsYield
With sulfuric acid; hydrogen bromide In water for 10h; Heating;A n/a
B 49%
C 37%
D n/a
Pentaerythritol
115-77-5

Pentaerythritol

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

Conditions
ConditionsYield
With sulfuric acid; hydrogen bromide; acetic acid Reflux;34%
With hydrogen bromide
With hydrogen bromide at 125℃;
Pentaerythritol
115-77-5

Pentaerythritol

A

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

B

2,2-bis(bromomethyl)-3-bromo-propan-1-ol
1522-92-5

2,2-bis(bromomethyl)-3-bromo-propan-1-ol

Conditions
ConditionsYield
With hydrogen bromide at 125℃;
Pentaerythritol
115-77-5

Pentaerythritol

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

Conditions
ConditionsYield
at 125℃;
Pentaerythritol
115-77-5

Pentaerythritol

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

A

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

B

2,2-bis(bromomethyl)-3-bromo-propan-1-ol
1522-92-5

2,2-bis(bromomethyl)-3-bromo-propan-1-ol

Conditions
ConditionsYield
at 125℃;
Pentaerythritol
115-77-5

Pentaerythritol

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

Conditions
ConditionsYield
With aqueous HBr; HBr gas In ice-water; hydrogen bromide; chlorobenzene
Octanoic acid
124-07-2

Octanoic acid

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

diethyl acetal
105-57-7

diethyl acetal

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

5,5-bis(bromomethyl)-2-methyl-1,3-dioxane
13727-36-1

5,5-bis(bromomethyl)-2-methyl-1,3-dioxane

Conditions
ConditionsYield
With acetic acid for 1h; Heating;100%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

2,2-bis(azidomethyl)propan-1,3-diol
104274-80-8

2,2-bis(azidomethyl)propan-1,3-diol

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 120℃; for 20h;100%
With sodium azide In dimethyl sulfoxide at 110℃; for 16h; Inert atmosphere;95.3%
With sodium azide; sodium hydride In N,N-dimethyl-formamide at 120℃; for 24h;95%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

5,5-bis-bromomethyl-2,2-dimethyl-[1,3]dioxane
43153-20-4

5,5-bis-bromomethyl-2,2-dimethyl-[1,3]dioxane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetone for 2h; Ambient temperature;100%
With toluene-4-sulfonic acid at 0 - 20℃; for 2h;100%
With toluene-4-sulfonic acid In acetone at 0 - 20℃; for 2h;100%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

dimethyldibromosilane
4095-10-7

dimethyldibromosilane

C7H14Br2O2Si

C7H14Br2O2Si

Conditions
ConditionsYield
Stage #1: bis(bromomethyl)bis(hydroxymethyl)methane; dimethyldibromosilane In diethylene glycol dimethyl ether at 10 - 50℃; for 2h;
Stage #2: With triethylamine acid binding agent In diethylene glycol dimethyl ether for 5h; Solvent; Reagent/catalyst;
99.1%
formaldehyd
50-00-0

formaldehyd

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

5,5-Bis(bromomethyl)[1,3]dioxane
22633-46-1

5,5-Bis(bromomethyl)[1,3]dioxane

Conditions
ConditionsYield
With hydrogenchloride In water at 50℃;98%
With hydrogenchloride Heating;96%
With acid
hydrogenchloride In water for 12h; Heating / reflux;
With hydrogenchloride In water for 12h; Reflux;2.544 g
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

2,2-bis(iodomethyl)-1,3-propanediol
3296-88-6

2,2-bis(iodomethyl)-1,3-propanediol

Conditions
ConditionsYield
With potassium iodide In acetone for 24h; Reagent/catalyst; Darkness; Reflux;97.5%
With sodium iodide In acetone for 72h; Heating;96%
With sodium iodide In acetone for 72h; Finkelstein Reaction; Reflux; Inert atmosphere;83%
Multi-step reaction with 2 steps
1: ethanolic KOH-solution
2: HI
View Scheme
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

4-mercaptodibenzothiophene
82884-38-6

4-mercaptodibenzothiophene

C29H24O2S4

C29H24O2S4

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 75℃; for 0.5h; Inert atmosphere;97%
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

1,1′-(2,2-bis(hydroxymethyl)propane-1,3-diyl)bis(3-methyl-1H-imidazol-3-ium) bromide

1,1′-(2,2-bis(hydroxymethyl)propane-1,3-diyl)bis(3-methyl-1H-imidazol-3-ium) bromide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 8h;95.25%
at 150℃; for 8h;95.25%
at 150℃; for 8h;95.25%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

benzaldehyde
100-52-7

benzaldehyde

5,5‐bis(bromomethyl)‐2‐phenyl‐1,3‐dioxane
3733-29-7

5,5‐bis(bromomethyl)‐2‐phenyl‐1,3‐dioxane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 120℃; for 4h;95%
With toluene-4-sulfonic acid In benzene Reflux;91.6%
With toluene-4-sulfonic acid90%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

m-nitrobenzoic acid chloride
121-90-4

m-nitrobenzoic acid chloride

2,2-bis(bromomethyl)-1,3-(m-nitrobenzoyloxy)propane
338447-26-0

2,2-bis(bromomethyl)-1,3-(m-nitrobenzoyloxy)propane

Conditions
ConditionsYield
With pyridine In butanone at 50℃; for 2h; Heating / reflux;94.4%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

2,2-bis-bromomethyl-1,3-bis-(4-nitro-benzoyloxy)-propane

2,2-bis-bromomethyl-1,3-bis-(4-nitro-benzoyloxy)-propane

Conditions
ConditionsYield
With pyridine In butanone at 20℃; for 2h; Heating / reflux;94%
With benzene
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

mono-4-methoxytrityl chloride
14470-28-1

mono-4-methoxytrityl chloride

2,2-bis(bromomethyl)-3-(4-methoxytrityloxy)propanol
317366-29-3

2,2-bis(bromomethyl)-3-(4-methoxytrityloxy)propanol

Conditions
ConditionsYield
With pyridine at 20℃;94%
With pyridine for 20h; Etherification;74%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

terephthalaldehyde,
623-27-8

terephthalaldehyde,

C18H22Br4O4
1370546-52-3

C18H22Br4O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene Inert atmosphere; Dean-Stark; Reflux;92%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

2-oxo-2H-chromene-3-carboxylic acid cesium salt
301165-23-1

2-oxo-2H-chromene-3-carboxylic acid cesium salt

2,2-bis(coumarin-3-carbonyl-oxymethyl)-1,3-propanediol
338447-55-5

2,2-bis(coumarin-3-carbonyl-oxymethyl)-1,3-propanediol

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 2h;88%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

[3-(bromomethyl)oxetan-3-yl]methanol
22633-44-9

[3-(bromomethyl)oxetan-3-yl]methanol

Conditions
ConditionsYield
With ethanol; sodium for 2h; Reflux;87%
With sodium ethanolate In ethanol at 20℃; for 4h;65%
With sodium ethanolate In ethanol; dichloromethane52%
1,3-dioxolane-2-spirocyclohexane
177-10-6

1,3-dioxolane-2-spirocyclohexane

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

3,3-bis(bromomethyl)-1,5-dioxaspiro<5.5>undecane
121705-21-3

3,3-bis(bromomethyl)-1,5-dioxaspiro<5.5>undecane

Conditions
ConditionsYield
With hydrogenchloride 1) r.t., 45 deg C, 2) 45 deg C, 1 h;85.8%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

3-nitrocinnamoyl chloride
141236-48-8, 35418-05-4

3-nitrocinnamoyl chloride

2,2-bis(bromomethyl)-1,3-(m-nitrocinnamoyloxy)propane
338447-40-8

2,2-bis(bromomethyl)-1,3-(m-nitrocinnamoyloxy)propane

Conditions
ConditionsYield
With pyridine In butanone at 40℃; Heating / reflux;83.2%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

acetic anhydride
108-24-7

acetic anhydride

2,2-bis(bromomethyl)-1,3-diacetoxypropane
3492-43-1

2,2-bis(bromomethyl)-1,3-diacetoxypropane

Conditions
ConditionsYield
With pyridine for 2h;82%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

C21H28Br2O2Si

C21H28Br2O2Si

Conditions
ConditionsYield
Stage #1: bis(bromomethyl)bis(hydroxymethyl)methane With dmap; triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere;
Stage #2: tert-butylchlorodiphenylsilane In dichloromethane at 0 - 25℃; for 11h; Inert atmosphere;
82%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

pentaerythritol tetrabromide
3229-00-3

pentaerythritol tetrabromide

Conditions
ConditionsYield
Stage #1: bis(bromomethyl)bis(hydroxymethyl)methane With p-toluenesulfonyl chloride In pyridine at 0 - 20℃; for 12h; Large scale; Green chemistry;
Stage #2: With sodium bromide In diethylene glycol at 140 - 150℃; for 24h; Temperature; Reagent/catalyst; Large scale; Green chemistry;
80%
With pyridine; p-toluenesulfonyl chloride; sodium bromide In PEG-600
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

hex-5-ynoic acid
53293-00-8

hex-5-ynoic acid

C11H16Br2O3

C11H16Br2O3

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 120℃; for 8h; Temperature; Time; Dean-Stark;78%
2,3-dimethoxythiophene
51792-34-8

2,3-dimethoxythiophene

bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

3,3-bis(bromomethyl)-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine
701209-98-5

3,3-bis(bromomethyl)-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 120℃; for 24h;75%
With toluene-4-sulfonic acid In toluene Heating;73%
With toluene-4-sulfonic acid In toluene at 110℃; for 24h;
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

2-chlorophenyl dichlorophosphate
15074-54-1

2-chlorophenyl dichlorophosphate

5,5-bis-bromomethyl-2-(2-chloro-phenoxy)-[1,3,2]dioxaphosphinane 2-oxide

5,5-bis-bromomethyl-2-(2-chloro-phenoxy)-[1,3,2]dioxaphosphinane 2-oxide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 5h;75%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

Methyl 3-mercaptopropionate
2935-90-2

Methyl 3-mercaptopropionate

dimethyl 3,3'-((2,2-bis(hydroxymethyl)propane-1,3-diyl)bis(sulfanediyl))dipropanoate

dimethyl 3,3'-((2,2-bis(hydroxymethyl)propane-1,3-diyl)bis(sulfanediyl))dipropanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 24h; Inert atmosphere;75%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

4-chlorophenylphosphorodichloridate
772-79-2

4-chlorophenylphosphorodichloridate

5,5-Bis-bromomethyl-2-(4-chloro-phenoxy)-[1,3,2]dioxaphosphinane 2-oxide
35652-38-1

5,5-Bis-bromomethyl-2-(4-chloro-phenoxy)-[1,3,2]dioxaphosphinane 2-oxide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;73%
With pyridine
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

acetophenone
98-86-2

acetophenone

5,5-bis(bromomethyl)-2-methyl-2-phenyl-1,3-dioxane
943966-90-3

5,5-bis(bromomethyl)-2-methyl-2-phenyl-1,3-dioxane

Conditions
ConditionsYield
With toluene-4-sulfonic acid Reflux;73%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

n-propyl dichlorophosphite
13040-68-1

n-propyl dichlorophosphite

5,5-Bis-bromomethyl-2-propoxy-[1,3,2]dioxaphosphinane

5,5-Bis-bromomethyl-2-propoxy-[1,3,2]dioxaphosphinane

Conditions
ConditionsYield
With triethylamine In diethyl ether at 10℃;70%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

4-bromophenyl carbamidophosphoric acid dichloride
86623-97-4

4-bromophenyl carbamidophosphoric acid dichloride

1-(5,5-bis-bromomethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-3-(4-bromo-phenyl)-urea

1-(5,5-bis-bromomethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-3-(4-bromo-phenyl)-urea

Conditions
ConditionsYield
Stage #1: bis(bromomethyl)bis(hydroxymethyl)methane; 4-bromophenyl carbamidophosphoric acid dichloride With triethylamine In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: In tetrahydrofuran at 30 - 40℃; for 5h;
70%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

5,5-Bis-bromomethyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide
38578-25-5

5,5-Bis-bromomethyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;70%
bis(bromomethyl)bis(hydroxymethyl)methane
3296-90-0

bis(bromomethyl)bis(hydroxymethyl)methane

2,2-bis(mercaptomethyl)-1,3-propanediol
19333-66-5

2,2-bis(mercaptomethyl)-1,3-propanediol

Conditions
ConditionsYield
With sodium hydrogen sulfide monohydrate In N,N-dimethyl-formamide at 50℃; for 48h; Solvent; Temperature;70%
With sodium hydrogen sulfide monohydrate In N,N-dimethyl-formamide at 50℃; for 48h;70%
Multi-step reaction with 2 steps
1: sodium tetrasulfide; ethanol
2: sodium; liquid ammonia
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 144 h / 20 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sulfur; sodium sulfide / N,N-dimethyl-formamide / 120 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux
View Scheme

3296-90-0Relevant articles and documents

-

Zelinski

, (1913)

-

Mimicking biological membranes with programmable glycan ligands self-assembled from amphiphilic Janus glycodendrimers

Zhang, Shaodong,Moussodia, Ralph-Olivier,Sun, Hao-Jan,Leowanawat, Pawaret,Muncan, Adam,Nusbaum, Christopher D.,Chelling, Kathleen M.,Heiney, Paul A.,Klein, Michael L.,André, Sabine,Roy, René,Gabius, Hans-J.,Percec, Virgil

supporting information, p. 10899 - 10903 (2015/03/30)

An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm. By simple injection of their THF solutions into water or buffer, all of the Janus compounds self-assembled into uniform, stable, and soft unilamellar vesicles, denoted glycodendrimersomes. The mixed constellation topology glycodendrimersomes were demonstrated to be most efficient in binding plant, bacterial, and human lectins. This evidence with biomedically relevant receptors offers a promising perspective for the application of such glycodendrimersomes in targeted drug delivery, vaccines, and other areas of nanomedicine.

Host-guest complexes of cucurbit[8]uril with some pentaerythritol derivative guests

Li, Xian-Mei,Fan, Fan,Lu, Jing-Song,Xue, Sai-Feng,Zhang, Yun-Qian,Zhu, Qian-Jiang,Tao, Zhu,Lawrance, Geofferey A.,Wei, Gang

scheme or table, p. 1088 - 1095 (2011/07/08)

A series of first generation dendritic guests from pentaerythritol derivatives have been designed and synthesized. Investigation of the complex structures of cucurbit[8]uril (Q[8]) and the guests based on the 1H NMR technique have revealed that the host Q[8] selectively included different branch(es) of the first generation dendritic guests and formed inclusion complexes with different structural conformations. The experimental results obtained from electronic absorption spectroscopy showed that the 1:1 ratio of Q[8]-based host-guest inclusion complexes have moderate stability with an average formation constants of 104 L mol-1. The single crystal structures of some of the guests (g5 and g6) and Q[8]-guest complexes (Q[8]-g4 and Q[8]-g6) further confirm but in some cases contradict the research results of the 1H NMR technique and electronic absorption spectroscopy in aqueous solution. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2011.

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