33050-38-3

Basic information

• Product Name: 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine
• Synonyms: 3,6-Dichloro-s-triazolo[4,3-b]pyridazine
• CAS NO: 33050-38-3
• Molecular Formula: C₅H₂Cl₂N₄
• Molecular Weight: 189
• Product Categories: Halides;Fused Ring Systems;Building Blocks;Imidazo[x,x-y]pyridazine
• Mol File: 33050-38-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 140-143°C
• Appearance: /
• Density: 1.90
• Refractive Index: 1.807
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine(33050-38-3)
• EPA Substance Registry System: 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine(33050-38-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 33050-38-3(Hazardous Substances Data)

Usage

General Description

3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine is a chemical compound with the molecular formula C6H2Cl2N4. It is a heterocyclic compound that contains both nitrogen and chlorine atoms in its structure. 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine is used in the pharmaceutical industry as a building block in the synthesis of various pharmaceutical drugs. It possesses a unique structure that makes it suitable for use in drug discovery and development. Its chemical properties and reactivity make it a valuable tool for medicinal chemistry research and drug design. Additionally, its structure makes it potentially useful in the development of new therapeutic agents.

InChI:InChI=1/C5H2Cl2N4/c6-3-1-2-4-8-9-5(7)11(4)10-3/h1-2H

Upstream product

• 33050-32-7 6-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-3-ol 
• 33050-32-7 6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one 
• 158607-17-1 3-(2,3-dibromomethylenehydrazino)-6-chloropyridazine 
• 158607-16-0 6-chloro-3-methylenehydrazinopyridazine 
• 7197-01-5 6-chloro-3-methyl-1,2,4-triazolo<4,3-b>pyridazine 
• 17284-97-8 3-Chloro-6-hydrazinopyridazine 
• 541-41-3 chloroformic acid ethyl ester 
• 28593-24-0 6-chloro[1,2,4]triazolo[4,3-b]pyridazine 

Downstream Products

• 1429024-67-8 6-(4'-fluorobiphenyl-2-yloxy)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429024-70-3 6-(2',4'-difluorobiphenyl-2-yloxy)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-61-5 5-(2-(3-chloro-[1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)-4-(trifluoromethyl)phenyl)-N,N-dimethylpyridin-2-amine 
• 1429025-06-8 3-chloro-6-(4-acetamidobiphenyl-2-yloxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-29-5 3-chloro-6-(4-trifluoromethyl-3'-aminocarbonylbiphenyl-2-yloxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-35-3 3-chloro-6-(2-(2-fluoropyridin-3-yl)-5-(trifluoromethyl)phenoxy)-[1,2_,4]triazolo[4,3-b]pyridazine 
• 1429025-60-4 3-chloro-6-(2-(6-chloropyridin-3-yl)-5-(trifluoromethyl)phenoxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429024-44-1 6-(biphenyl-3-yloxy)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-62-6 3-chloro-6-(2-(thiazol-4-yl)phenoxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-81-9 3-chloro-6-(2-(morpholinomethyl)-5-(trifluoromethyl)phenoxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-88-6 3-chloro-6-(2-(pyridin-3-yl)-3-(trifluoromethyl)phenoxy)-[1_.2_.4]triazolo[4,3-b]pyridazine 
• 1429025-72-8 3-chloro-6-{[4-methoxy-3'-(trifluoromethyl)biphenyl-2-yl]oxy}-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-77-3 3-chloro-6-(4'-chloro-5-fluorobiphenyl-2-yloxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-82-0 3-chloro-6-(2-(2-methylpyridin-3-yl)-5-(trifluoromethyl)phenoxy)-[1,2,4]triazolo[4,3-b]pyridazine 

Relevant articles and documents

HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE

The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Synthesis and Reactivity of some 1,2,4-Triazolopyridazine Derivatives

The triazolopyridazine derivatives were obtained in the reaction of 3-chloro-6-hydrazinopyridazine with acetic acid and ethyl chloroformate.Acting on 6-chloro-3-methyl-1,2,4-triazolopyridazine with phosphorus pentachloride, a methyl group in position 3 has unexpectedly been exchanged by chlorine.The mechanism of fusing the triazole ring to the pyridazine system has been studied by the reaction of 3-chloro-6-hydrazinopyridazine with formaldehyde, acetaldehyde, and treatment the resulting Schiff bases by bromine in acetic acid with sodium acetate added.Key words: 1,2,4-Triazolopyridazines, nucleophilic substitution, cyclization mechanism