330794-09-7

Basic information

• Product Name: TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE
• Synonyms: TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE
• CAS NO: 330794-09-7
• Molecular Formula: C₁₁H₁₃BrClNO₂
• Molecular Weight: 306.58342
• Mol File: 330794-09-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 302.7 °C at 760 mmHg
• Flash Point: 136.9 °C
• Appearance: /
• Density: 1.484 g/cm³
• Water Solubility: at 25 deg C (mg/L): 1.205
• CAS DataBase Reference: TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE(330794-09-7)
• EPA Substance Registry System: TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE(330794-09-7)

Safety Data

• Hazardous Substances Data: 330794-09-7(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-bromo-2-chlorophenylcarbamate is a chemical compound used as a pesticide and insecticide, specifically as a carbamate insecticide. It is a white crystalline solid with a molecular formula of C11H14BrClNO2 and a molecular weight of 293.6 g/mol. This chemical is toxic to aquatic organisms and may cause long-term adverse effects in the aquatic environment. It is important to handle and dispose of tert-butyl 4-bromo-2-chlorophenylcarbamate with caution and in accordance with appropriate safety measures to minimize harm to the environment and human health.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 38762-41-3 2-chloro-4-bromoaniline 
• 106-40-1 4-bromo-aniline 
• 131818-17-2 tert-butyl (4-bromophenyl)carbamate 

Downstream Products

• 1432909-92-6 2-chloro-4-(3-methylpyrazin-2-yl)aniline 
• 1648864-28-1 [2-chloro-4-(6-methylpyrazin-2-yl)phenyl]boronic acid 
• 330794-10-0 tert-butyl-N-[2-chloro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate 

Relevant articles and documents

Highly ortho-Selective Chlorination of Anilines Using a Secondary Ammonium Salt Organocatalyst

An organocatalytic, highly facile, efficient, and regioselective ortho-chlorination of anilines is described. A secondary ammonium chloride salt has been employed as the catalyst and the reaction can be conducted at room temperature without protection from air and moisture. In addition, the reaction is readily scalable and the catalyst can be recycled and reused. This catalytic protocol has been applied to the efficient synthesis of a highly potent c-Met kinase inhibitor. Mechanistic studies revealed that unique structural features of the secondary ammonium chloride salt are important for both the catalysis and regioselectivity of the electrophilic ortho-chlorination.

Pyrazolopyrimidines as therapeutic agents

The present invention is directed to pyrazolopyrimidine derivatives of formula (I) wherein the substituents are defined herein, which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.

Pyrazolopyrimidines as therapeutic agents

The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R2, and R3 are defined as described herein.