330865-56-0Relevant articles and documents
Synthesis and evaluation of unsymmetrical heterocyclic thioureas as potent β-glucuronidase inhibitors
Taha, Muhammad,Ismail, Nor Hadiani,Jamil, Waqas,Khan, Khalid Mohammed,Salar, Uzma,Kashif, Syed Muhammad,Rahim, Fazal,Latif, Yawar
, p. 3166 - 3173 (2015/08/03)
Thiourea analogs 1-20 were synthesized and evaluated for their in vitro β-glucuronidase inhibitory potential. The compounds 9 (0.86 ± 0.01 μM), 6 (1.24 ± 0.01 μM), 16 (1.64 ± 0.02 μM) and 15 (2.12 ± 0.02 μM) showed potent activity. Other analogs 1-5, 7, 8
Fluorous electrophilic scavengers for solution-phase parallel synthesis
Zhang, Wei,Chen, Christine Hiu-Tung,Nagashima, Tadamichi
, p. 2065 - 2068 (2007/10/03)
A fluorous isatoic anhydride and isocyanate are synthesized and used as scavengers for amines in solution-phase parallel synthesis of urea, thiourea, and β-hydroxyamine analogs. The resulting fluorous derivatives are readily separated from the reaction mi