33125-57-4

Basic information

• Product Name: Benzene, 1-(1,1-dimethylpropyl)-3-methyl-
• CAS NO: 33125-57-4
• Molecular Formula: C12H18
• Molecular Weight: 162.275
• Mol File: 33125-57-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1,1-dimethylpropyl)-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1,1-dimethylpropyl)-3-methyl-(33125-57-4)
• EPA Substance Registry System: Benzene, 1-(1,1-dimethylpropyl)-3-methyl-(33125-57-4)

Safety Data

• Hazardous Substances Data: 33125-57-4(Hazardous Substances Data)

Upstream product

• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 585-74-0 3-Methylacetophenone 
• 75-24-1 trimethylaluminum 
• 22040-30-8 m-(1,2-dimethylpropyl)toluene 
• 22040-31-9 p-(1,2-dimethylpropyl)toluene 
• 4237-70-1 4-(1,1-dimethylpropyl)toluene 
• 5208-37-7 8-hydroxy-m-cymene 
• 925-90-6 ethylmagnesium bromide 
• 543-59-9 1-Chloropentane 
• 108-88-3 toluene 
• 594-36-5 2-methyl-2-butylchloride 
• 513-35-9 2-methyl-but-2-ene 

Downstream Products

• 88070-01-3 2-methyl-4-tert-amyldiphenylmethane 
• 88070-07-9 2-tert-amyl-4-methyldiphenylmethane 
• 88070-03-5 3-methyl-5-tert-amyldiphenylmethane 
• 4237-70-1 4-(1,1-dimethylpropyl)toluene 
• 22040-31-9 p-(1,2-dimethylpropyl)toluene 
• 22040-30-8 m-(1,2-dimethylpropyl)toluene 
• 121-91-5 isophthalic acid 
• 94055-50-2 4-(1,1-Dimethyl-propyl)-2-methyl-1-(1-phenyl-ethyl)-benzene 

Relevant articles and documents

Access to "friedel-Crafts-Restricted" tert -alkyl aromatics by activation/methylation of tertiary benzylic alcohols

Herein we describe a two-step protocol to prepare m-tert-alkylbenzenes. The appropriate tertiary benzylic alcohols are activated with SOCl2 or concentrated HCl and then treated with trimethylaluminum, affording the desired products in 68-97% yields (22 examples). This reaction sequence is successful in the presence of a variety of functional groups, including acid-sensitive and Lewis-basic groups. In addition to t-Bu groups, 1,1-dimethylpropyl and 1-ethyl-1-methylpropyl groups can also be installed using this method.