3315-19-3

Basic information

• Product Name: 4-(1,3-benzoxazol-2-yl)benzenol
• Synonyms: 4-(1,3-benzoxazol-2-yl)benzenol;4-BENZOOXAZOL-2-YL-PHENOL;Zinc03101849;4-(BENZO[D]OXAZOL-2-YL)PHENOL
• CAS NO: 3315-19-3
• Molecular Formula: C₁₃H₉NO₂
• Molecular Weight: 211.219
• Mol File: 3315-19-3.mol
• Article Data: 46

Chemical Properties

• Melting Point: 250 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 355.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.293±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.89±0.15(Predicted)
• CAS DataBase Reference: 4-(1,3-benzoxazol-2-yl)benzenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,3-benzoxazol-2-yl)benzenol(3315-19-3)
• EPA Substance Registry System: 4-(1,3-benzoxazol-2-yl)benzenol(3315-19-3)

Safety Data

• Hazardous Substances Data: 3315-19-3(Hazardous Substances Data)

Usage

General Description

4-(1,3-benzoxazol-2-yl)benzenol, also known as 2-hydroxy-4-(2'-hydroxyphenyl)benzoxazole, is a chemical compound that belongs to the class of benzoxazole derivatives. It is a white to off-white powder that is soluble in organic solvents such as methanol and ethyl acetate. 4-(1,3-benzoxazol-2-yl)benzenol has diverse applications in the field of pharmaceuticals, and it is used as a building block in the synthesis of various pharmaceutical drugs. Additionally, it has shown potential as a fluorescence probe for the detection of metal ions in analytical and environmental chemistry. However, it is important to handle this compound with caution as it may pose health hazards if not handled properly.

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 95-55-6 2-amino-phenol 
• 402-45-9 4-hydroxybenzotrifluoride 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 17065-03-1 4-hydroxybenzylidene-2-hydroxyaniline 
• 838-34-6 2-(p-methoxyphenyl)benzoxazole 
• 117649-29-3 2-(4-methoxybenzylideneamino)phenol 
• 123-11-5 4-methoxy-benzaldehyde 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 1040034-32-9 C₁₃H₁₀INO₂ 
• 17065-03-1 cis-N-(p-Hydroxybenzylidene)-o-aminophenol 
• 7464-55-3 N-(o-methoxyphenyl)-4-methoxybenzamide 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 1236771-70-2 2-[4-(5-bromopentyloxy)phenyl]-1,3-benzoxazole 
• 1334551-95-9 2-(4-(4-bromobutoxy)phenyl)benzo[d]oxazole 

Relevant articles and documents

Synthesis, Characterization and DFT-D Studies of 2-Aminoethoxycalix[4]resorcinarenes: A Novel Heterogeneous Organocatalyst

The present article reports the synthesis of two novel supramolecular architectures, Phenyl(octa-2-aminoethoxy)calix[4]resorcinarene and 2-Aminoethoxyphenyl-(octa-2-aminoethoxy)calix[4]resorcinarene via surface functionalization and describes their applic

SSAO INHIBITOR

The present invention provides an SSAO inhibitor and an application thereof in preparing a drug for treating a disease related to SSAO. In particular, the present invention provides a compound shown in formula (IV) and a pharmaceutically acceptable salt thereof.

Sulfur-Promoted Synthesis of Benzoxazoles from 2-Aminophenols and Aldehydes

Elemental sulfur (S8) was found to be an excellent stoichiometric oxidant to promote oxidative condensation of 2-aminophenols with a wide range of aldehydes, including aliphatic aldehyde such as cyclohexanecarboxaldehyde. The reactions were catalyzed by sodium sulfide in the presence of DMSO as an additive. The benzoxazole products were obtained in satisfactory yields. The reaction conditions could be applied to larger syntheses (10–50 mmol).