33208-98-9

Basic information

• Product Name: H-PRO-NHCH3 HCL
• Synonyms: L-PROLINE-METHYLAMIDE HYDROCHLORIDE;H-PRO-NHCH3 HCL;H-PRO-NHME HCL;(S)-N-Methyl-2-pyrrolidinecarboxaMide HCl;H-Pro-NHCH3 hydrochloride;(S)-N-Methyl-2-pyrrolidinecarboxamidehydrochloride;(S)-Pyrrolidine-2-carboxylic acid methylamide hydrochloride;(S)-Pyrrolidine-2-carboxylic acid amide hydrochloride
• CAS NO: 33208-98-9
• Molecular Formula: C₆H₁₂N₂O*ClH
• Molecular Weight: 164.63
• Mol File: 33208-98-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: H-PRO-NHCH3 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-PRO-NHCH3 HCL(33208-98-9)
• EPA Substance Registry System: H-PRO-NHCH3 HCL(33208-98-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 33208-98-9(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Upstream product

• 88815-87-6 tert-butyl (2S)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate 
• 74-89-5 methylamine 
• 7531-52-4 L-prolinamide 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 3392-10-7 tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester 

Downstream Products

• 117669-16-6 1-(4-Methylphenylazo)pyrrolidine-2-methylcarboxamide 
• 117669-15-5 (S)-1-(m-Tolyl-diazenyl)-pyrrolidine-2-carboxylic acid methylamide 
• 117669-19-9 (S)-1-(4-Hydroxy-phenyl-diazenyl)-pyrrolidine-2-carboxylic acid methylamide 
• 117669-13-3 1-(4-Chlorophenylazo)pyrrolidine-2-methylcarboxamide 
• 117669-18-8 1-(4-Ethoxyphenylazo)pyrrolidine-2-methylcarboxamide 
• 117669-12-2 1-(4-Carbethoxyphenylazo)pyrrolidine-2-methylcarboxamide 
• 155540-08-2 acryloyl-L-prolyl-N'-methylamide 
• 131792-56-8 Boc-Asp(OBzl)-Pro-NHMe 
• 1262660-98-9 N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide 
• 52060-82-9 L-proline methylamide 
• 441353-48-6 Piv-L-Ser(OBn)-L-Pro-NHMe 
• 441353-47-5 Boc-L-Ser(OBn)-L-Pro-NHMe 
• 940312-60-7 [(S)-1-Benzyl-2-((S)-2-methylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 117669-17-7 1-(4-Methoxyphenylazo)pyrrolidine-2-methylcarboxamide 

Relevant articles and documents

A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents

While organic donor-acceptor (D-A) molecules are widely employed in multiple areas, the application of more D-A molecules could be limited because of an inherent polarity sensitivity that inhibits photochemical processes. Presented here is a facile chemical modification to attenuate solvent-dependent mechanisms of excited-state quenching through addition of a β-carbonyl-based polar substituent. The results reveal a mechanism wherein the β-carbonyl substituent creates a structural buffer between the donor and the surrounding solvent. Through computational and experimental analyses, it is demonstrated that the β-carbonyl simultaneously attenuates two distinct solvent-dependent quenching mechanisms. Using the β-carbonyl substituent, improvements in the photophysical properties of commonly used D-A fluorophores and their enhanced performance in biological imaging are shown.

Highly efficient stereoconservative amidation and deamidation of α-amino acids

(Chemical Equation Presented) An overall stereoconservative protection and deprotection method of amino and carboxyl groups is presented. N-Phthaloyl N-alkyl secondary amides of α-amino acids can be generated from corresponding N-phthaloyl amino acids by coupling reaction of N-alkylamines using mixed anhydride method. These secondary amides can be transformed by thermal rearrangement of intermediate nitrosoamides to O-alkyl esters with retention of configuration and excellent yields.

REACTIVITY AND MECHANISM OF THE ANTITUMOR ACTION OF TRIAZENES. V. INTERACTION OF AROMATIC DIAZODERIVATIVES WITH THE METHYLAMIDE OF L-PROLINE

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