332903-74-9

Basic information

• Product Name: (2-CHLORO-6-FLUOROPHENYL)-P-TOLYL-AMINE
• Synonyms: (2-CHLORO-6-FLUOROPHENYL)-P-TOLYL-AMINE;2-chloro-6-fluoro-N-p-tolylbenzenaMine
• CAS NO: 332903-74-9
• Molecular Formula: C₁₃H₁₁ClFN
• Molecular Weight: 235.68
• Mol File: 332903-74-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-CHLORO-6-FLUOROPHENYL)-P-TOLYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-6-FLUOROPHENYL)-P-TOLYL-AMINE(332903-74-9)
• EPA Substance Registry System: (2-CHLORO-6-FLUOROPHENYL)-P-TOLYL-AMINE(332903-74-9)

Safety Data

• Hazardous Substances Data: 332903-74-9(Hazardous Substances Data)

Usage

General Description

The chemical (2-chloro-6-fluorophenyl)-p-tolyl-amine, also known by its IUPAC name 1-(2-chloro-6-fluorophenyl)-4-methylbenzene-1-amine, is an organic compound with the molecular formula C13H11ClFN. It is a derivative of aniline and is commonly used in the synthesis of pharmaceuticals and agrochemicals. This chemical has potential applications in the field of medicinal chemistry and drug discovery due to its ability to interact with biological targets. It is important to handle this compound with care as it may pose health and environmental hazards if not properly managed.

Upstream product

• 106-38-7 para-bromotoluene 
• 363-51-9 2-chloro-6-fluoroaniline 
• 106-49-0 p-toluidine 
• 76144-87-1 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl 
• 309721-44-6 2-bromo-3-fluoro-chlorobenzene 
• 16634-82-5 N-(p-tolyl)-2-chloroacetamide 
• 623-03-0 4-Cyanochlorobenzene 
• 817621-52-6 4-(2-chloro-6-fluoro-phenylamino)benzoic acid ethyl ester 

Downstream Products

• 332903-78-3 2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide 
• 332903-83-0 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one 
• 220991-20-8 lumiracoxib 

Relevant articles and documents

Process for phenylacetic acid derivatives

A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.

Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds

Various new N-aryl oxindoles were synthesized as intermediates for the preparation of pharmacologically active 2-(N-arylamino)-phenylacetic acids. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures, in addition to Buchwald-arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles. Graphical Abstract.