334015-45-1

Basic information

• Product Name: 2-(methoxymethoxy)-4-(trifluoromethyl)benzaldehyde
• Synonyms: 2-(methoxymethoxy)-4-(trifluoromethyl)benzaldehyde
• CAS NO: 334015-45-1
• Molecular Weight: 234.175
• Mol File: 334015-45-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(methoxymethoxy)-4-(trifluoromethyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methoxymethoxy)-4-(trifluoromethyl)benzaldehyde(334015-45-1)
• EPA Substance Registry System: 2-(methoxymethoxy)-4-(trifluoromethyl)benzaldehyde(334015-45-1)

Safety Data

• Hazardous Substances Data: 334015-45-1(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 334018-79-0 1-(trifluoromethyl)-3-(methoxymethoxy)benzene 
• 58914-34-4 2-hydroxy-4-(trifluoromethyl)benzaldehyde 
• 13057-17-5 bromethyl methyl ether 
• 107-30-2 chloromethyl methyl ether 

Relevant articles and documents

Sequential Energy Transfer Catalysis: A Cascade Synthesis of Angularly-Fused Dihydrocoumarins

An operationally simple one-pot protocol has been developed to enable the conversion of diversely substituted cinnamic acid derivatives into angularly-fused dihydrocoumarins (up to 94%). Inspired by coumarin biosynthesis, this reaction cascade harnesses photochemical E → Z alkene isomerization enabled by energy transfer catalysis using inexpensive thioxanthen-9-one (TX) under irradiation at 402 nm. Subsequent lactonization generates the heterocyclic core prior to a second photosensitization event to induce a [2 + 2] cycloaddition, again mediated by TX. The tetracyclic products are generated efficiently, and proof of the structure was established by X-ray crystallography. Mechanistic investigations, including structural probes and NMR reaction monitoring, support the postulated order of events. The study underscores the synthetic value of inexpensive small-molecule organic photocatalysts in the generation of structural complexity via sequential ?€-bond activation.

Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation

A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.