33402-75-4Relevant articles and documents
Tetrahydropyrido[d]pyridazinones - Promising scaffolds for drug discovery
Yaremenko, Anatoliy G.,Volochnyuk, Dmitriy M.,Shelyakin, Vyacheslav V.,Grygorenko, Oleksandr O.
, p. 6799 - 6803 (2013/07/26)
An approach to the synthesis of all possible tetrahydropyrido[d] pyridazinones has been developed. The method relies on the catalytic hydrogenation of the corresponding aromatic counterparts, which were obtained by cyclization of the relevant dibromomethyl-substituted pyridinecarboxylates with hydrazine. The synthetic schemes include 4-5 steps starting from commercially available materials. The tetrahydropyrido[d]pyridazinone scaffolds are combinations of a saturated heterocycle (piperidine) and a privileged aromatic heterocycle (pyridazinone); hence they are promising starting points for the design in medicinal chemistry.
Multiple Paths for Photo-alkylation and -alkoxylation of 3-Pyridinecarboxylic Ester in Alcohol. Simultaneous Contribution of Several Kinds of Excited States
Sugimori, Akira,Tobita, Etsuo,Kumagai, Yasuyuki,Sato, Gen P.
, p. 1761 - 1766 (2007/10/02)
UV-irradiation of methyl 3-pyridinecarboxylate (1) in acidic alcoholic solutions brings about the alkoxylation and alkylation at the pyridine ring.Photoalkylation occurs in several paths: 1) alkylation initiated by the triplet ?-?* state, 2) alkylation initiated by the triplet n-?* state of the carbonyl moiety of the ester group, 3) alkylation initiated by exciplex between a free base form of 1 and a pyridinium form of 1, and 4) alkylation promoted by chloride ions.Photoalkoxylation originates from a singlet excited state of 1.In the photoreactions of 1 in strongly a cidic methanolic solutions acidified with H2SO4, three kinds of excited states (two kinds of triplet states for alkylation and a singlet state for alkoxylation) contribute simultaneously.